AIMC Topic: Lipase
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Variations of the chemical components and biological activities of Thymus capitatus essential oil from three regions in Palestine.
Scientific reports
May 10, 2025
Thymus capitatus is a widely utilized medicinal plant in Palestine. The main goal of this study was to assess the phytochemical content of T. capitatus essential oils (EOs) from three Palestinian regions using hydro-distillation. Furthermore, the EO ...
Representative training data sets are critical for accurate machine-learning classification of microscopy images of particles formed by lipase-catalyzed polysorbate hydrolysis.
Journal of pharmaceutical sciences
Jan 15, 2025
Polysorbate 20 (PS20) is commonly used as an excipient in therapeutic protein formulations. However, over the course of a therapeutic protein product's shelf life, minute amounts of co-purified host-cell lipases may cause slow hydrolysis of PS20, rel...
Inverse design of chemoenzymatic epoxidation of soyabean oil through artificial intelligence-driven experimental approach.
Bioresource technology
Sep 1, 2024
This paper presents an inverse design methodology that utilizes artificial intelligence (AI)-driven experiments to optimize the chemoenzymatic epoxidation of soyabean oil using hydrogen peroxide and lipase (Novozym 435). First, experiments are conduc...
Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.
Journal of lipid research
Dec 20, 2023
Lipolysis is an essential metabolic process that releases unesterified fatty acids from neutral lipid stores to maintain energy homeostasis in living organisms. Adipose triglyceride lipase (ATGL) plays a key role in intracellular lipolysis and can be...
Artificial Intelligence Aided Lipase Production and Engineering for Enzymatic Performance Improvement.
Journal of agricultural and food chemistry
Oct 6, 2023
With the development of artificial intelligence (AI), tailoring methods for enzyme engineering have been widely expanded. Additional protocols based on optimized network models have been used to predict and optimize lipase production as well as prope...
Enhancement of protein thermostability by three consecutive mutations using loop-walking method and machine learning.
Scientific reports
Jun 4, 2021
We developed a method to improve protein thermostability, "loop-walking method". Three consecutive positions in 12 loops of Burkholderia cepacia lipase were subjected to random mutagenesis to make 12 libraries. Screening allowed us to identify L7 as ...
Polymerase Chain Reaction
Molecular Conformation
Hot Temperature
Enzyme Stability
Plasmids
Lipase
Protein Engineering
Burkholderia cepacia
Mutagenesis
Hydrolases
Mutagenesis, Site-Directed
Machine Learning
Computational Biology
Escherichia coli
Kinetics
Molecular Dynamics Simulation
Proteins
Mutation
QSSR Modeling of Bacillus Subtilis Lipase A Peptide Collision Cross-Sections in Ion Mobility Spectrometry: Local Descriptor Versus Global Descriptor.
The protein journal
Jan 16, 2021
To investigate the structure-dependent peptide mobility behavior in ion mobility spectrometry (IMS), quantitative structure-spectrum relationship (QSSR) is systematically modeled and predicted for the collision cross section Ω values of totally 162 s...
Optimization and modelling of enzymatic polymerization of ε-caprolactone to polycaprolactone using Candida Antartica Lipase B with response surface methodology and artificial neural network.
Enzyme and microbial technology
Dec 5, 2018
Recently enzymatic catalysts have replaced organic and organometallic catalysts in the synthesis of bio-resorbable polymers. Enzymatic polymerization is considered as an alternative to conventional polymerization as they are less toxic, environmental...
Antioxidant and anti-glycation capacities of some medicinal plants and their potential inhibitory against digestive enzymes related to type 2 diabetes mellitus.
Journal of ethnopharmacology
Dec 21, 2017
ETHNOPHARMACOLOGICAL RELEVANCE: Plants preparations are used by traditional medicine in the treatment of various diseases, such as type-2 diabetes mellitus. Some medicinal plants are capable of controlling the complications of this metabolic disease ...
Enzymatic preparation of "functional oil" rich in feruloylated structured lipids with solvent-free ultrasound pretreatment.
Food chemistry
Dec 19, 2017
In this study, a series of functional oils rich in feruloylated structured lipids (FSLs) was prepared by enzymatic transesterification of ethyl ferulate (EF) with triglycerides under ultrasound pretreatment. A conversion of more than 92.7% and contro...
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