AIMC Topic: Lipid Bilayers

Clear Filters Showing 11 to 19 of 19 articles

Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Phosphatidylcholines Phosphatidylglycerols Erythrocytes Stereoisomerism Acinetobacter baumannii Escherichia coli Female Keratinocytes Methicillin-Resistant Staphylococcus aureus Animals Humans Enterococcus faecalis Mice, Inbred BALB C Hemolysis Anti-Bacterial Agents Amino Acid Sequence Lipid Bilayers Pseudomonas aeruginosa Peptidomimetics Microbial Sensitivity Tests
View on PubMed DOI

Synthetic Ion Channels and DNA Logic Gates as Components of Molecular Robots.

Chemphyschem : a European journal of chemical physics and physical chemistry Dec 8, 2017
A molecular robot is a next-generation biochemical machine that imitates the actions of microorganisms. It is made of biomaterials such as DNA, proteins, and lipids. Three prerequisites have been proposed for the construction of such a robot: sensors...
Ion Channels Nanopores Valinomycin DNA Lipid Bilayers Humans Neoplasms Aptamers, Nucleotide MicroRNAs Robotics
View on PubMed DOI

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

PLoS computational biology Oct 23, 2017
There is growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in sensing and regulating cellular response to diverse external signals. A MP must be expressed, correctly inserted and folded in a lipid bilay...
Humans Machine Learning Drug Design Structure-Activity Relationship HEK293 Cells Sequence Analysis, Protein Rhodopsin Cell Membrane Ion Channels Lipid Bilayers Subcellular Fractions
View on PubMed DOI

A Prediction Model for Membrane Proteins Using Moments Based Features.

BioMed research international Feb 15, 2016
The most expedient unit of the human body is its cell. Encapsulated within the cell are many infinitesimal entities and molecules which are protected by a cell membrane. The proteins that are associated with this lipid based bilayer cell membrane are...
Lipid Bilayers Models, Theoretical Amino Acids Cell Membrane Humans Neural Networks, Computer Membrane Proteins
View on PubMed DOI

TmDet 4.0: determining membrane orientation of transmembrane proteins from 3D structure.

Nucleic acids research Jul 7, 2025
During the structural determination of transmembrane proteins, one crucial piece of information is lost: the orientation of the protein within the lipid bilayer. The TmDet algorithm was developed in the early 2000s to determine the relative position ...
Software Algorithms Cell Membrane Protein Conformation Membrane Proteins Lipid Bilayers Models, Molecular Internet
View on PubMed DOI

Deep Learning-Assisted Nanocavity Sensor for Amphiphilic Biomarker Analysis.

Analytical chemistry Jul 1, 2025
Fluorescence enhancement using nanocavity structures is a promising approach for rapid detection of amphiphilic biomarkers, which are essential for diagnosing diseases such as cancer and infections. This paper presents the use of a silver nanocube (A...
Lipid Bilayers Spectrometry, Fluorescence Silver Humans Biomarkers Deep Learning Biosensing Techniques Gold Metal Nanoparticles
View on PubMed DOI

Learning transition path and membrane topological signatures in the folding pathway of bacteriorhodopsin (BR) fragment with artificial intelligence.

The Journal of chemical physics Mar 14, 2025
Membrane protein folding in the viscous microenvironment of a lipid bilayer is an inherently slow process that challenges experiments and computational efforts alike. The folding kinetics is moreover associated with topological modulations of the bio...
Artificial Intelligence Algorithms Thermodynamics Protein Folding Bacteriorhodopsins Molecular Dynamics Simulation Lipid Bilayers
View on PubMed DOI

Improving the accuracy and convergence of drug permeation simulations via machine-learned collective variables.

The Journal of chemical physics Jul 28, 2021
Understanding the permeation of biomolecules through cellular membranes is critical for many biotechnological applications, including targeted drug delivery, pathogen detection, and the development of new antibiotics. To this end, computer simulation...
Cholesterol Molecular Dynamics Simulation Phosphatidylcholines Algorithms Unsupervised Machine Learning Thermodynamics Pharmacokinetics Trimethoprim Lipid Bilayers
View on PubMed DOI

Artificial neural networks for the inverse design of nanoparticles with preferential nano-bio behaviors.

The Journal of chemical physics Aug 7, 2020
Safe and efficient use of ultrasmall nanoparticles (NPs) in biomedicine requires numerous independent conditions to be met, including colloidal stability, selectivity for proteins and membranes, binding specificity, and low affinity for plasma protei...
Neural Networks, Computer Protein Binding Nanoparticles Proteins Molecular Dynamics Simulation Lipid Bilayers
View on PubMed DOI
Popular Topics
Recent Journals