AIMC Topic: Lipids

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Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.

EBioMedicine Oct 7, 2023
BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic opti...
Aged Deep Learning Cognitive Dysfunction Humans Metabolome Alzheimer Disease Neuroimaging Magnetic Resonance Imaging Lipids
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Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning.

Journal of biomedical optics Jun 12, 2023
SIGNIFICANCE: The shortwave infrared (SWIR, to 2000 nm) holds promise for label-free measurements of water and lipid content in thick tissue, owed to the chromophore-specific absorption features and low scattering in this range. water and lipid est...
Emulsions Humans Deep Learning Water Lipids Wearable Electronic Devices
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Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach.

International journal of pharmaceutics May 2, 2023
To develop a combinatorial artificial-neural-network design-of-experiment (ANN-DOE) model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate ratio (FRR), and total flow rate (TFR) on the outcome responses of...
mRNA Vaccines Lipids Neural Networks, Computer Machine Learning
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The antidiabetic drug pioglitazone ameliorates betel-nut-induced carcinogenesis in mice by restoring normal lipid metabolism, reducing oxidative stress, and inducing apoptosis.

Journal of cancer research and therapeutics Apr 27, 2023
CONTEXT: Oral administration (2 mg mL-1) of aqueous extract of betel nut (AEBN) for 24 weeks induced oncogenic alterations in the liver of female Swiss Albino mice concomitant with aberrant lipid metabolism, overactivation of Akt/mTOR signaling, and ...
Areca Hypoglycemic Agents Nuts Apoptosis Lipid Metabolism Oxidative Stress TOR Serine-Threonine Kinases Female Carcinogenesis Lipids Mice Pioglitazone Animals Proto-Oncogene Proteins c-akt
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Acute Stress-Induced Changes in the Lipid Composition of Cow's Milk in Healthy and Pathological Animals.

Molecules (Basel, Switzerland) Jan 18, 2023
Producers of milk and dairy products have been faced with the challenge of responding to European society's demand for guaranteed animal welfare production. In recent years, measures have been taken to improve animal welfare conditions on farms and e...
Artificial Intelligence Female Animals Lipids Milk Haptoglobins Cattle Health Status
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Deep Learning for Chondrogenic Tumor Classification through Wavelet Transform of Raman Spectra.

Sensors (Basel, Switzerland) Oct 3, 2022
The grading of cancer tissues is still one of the main challenges for pathologists. The development of enhanced analysis strategies hence becomes crucial to accurately identify and further deal with each individual case. Raman spectroscopy (RS) is a ...
Vitamins Wavelet Analysis Humans Neoplasms Spectrum Analysis, Raman Lipids Deep Learning
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Implementation of Machine Learning Mechanism for Recognising Prostate Cancer through Photoacoustic Signal.

Contrast media & molecular imaging Sep 20, 2022
Biological tissues may be studied using photoacoustic (PA) spectroscopy, which can yield a wealth of physical and chemical data. However, it is really challenging to directly analyse these tissues because of a lot of data. Data mining techniques can ...
Machine Learning Algorithms Lipids Bayes Theorem Male Prostatic Neoplasms Humans Spectrum Analysis
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Predicting H NMR acyl chain order parameters with graph neural networks.

Computational biology and chemistry Aug 3, 2022
H NMR order parameters of the acyl chain of phospholipid membranes are an important indicator of the effects of molecules on membrane order, mobility, and permeability. So far, the evaluation procedures are case-by-case studies for every type of smal...
Lipids Magnetic Resonance Spectroscopy Software Magnetic Resonance Imaging Neural Networks, Computer
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Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach.

Drug development and industrial pharmacy May 19, 2022
OBJECTIVE: The present study was aimed to design and optimize brimonidine tartrate (BRT) loaded cationic-charged liposome formulation with enhanced trans-corneal drug permeation, prolonged corneal residence, and sustained drug release for effective o...
Particle Size Lipids Drug Carriers Drug Delivery Systems Cornea Brimonidine Tartrate Drug Liberation Liposomes
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Characterizing breast masses using an integrative framework of machine learning and CEUS-based radiomics.

Journal of ultrasound Jan 17, 2022
AIMS: We evaluated the performance of contrast-enhanced ultrasound (CEUS) based on radiomics analysis to distinguish benign from malignant breast masses.
Female Lipids Image-Guided Biopsy Breast Humans Machine Learning Retrospective Studies
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