AIMC Topic: Machine Learning

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Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets.

Cell reports. Medicine
Type 1 diabetes (T1D) is a chronic condition in which beta cells are destroyed by immune cells. Despite progress in immunotherapies that could delay T1D onset, early detection of autoimmunity remains challenging. Here, we evaluate the utility of mach...

Behavioral toxicological tracking analysis of Drosophila larvae exposed to polystyrene microplastics based on machine learning.

Journal of environmental management
Microplastics, as a pivotal concern within plastic pollution, have sparked widespread apprehension due to their ubiquitous presence. Recent research indicates that these minuscule plastic particles may exert discernible effects on the locomotor capab...

Assessment of machine learning algorithms and new hybrid multi-criteria analysis for flood hazard and mapping.

Environmental science and pollution research international
Floods in Iran cause a lot of damage in different places every year. The 2019 floods of the Gorgan and Atrak rivers basins in the north of Iran were one of the most destructive events in this country. Therefore, investigating the flood hazard of thes...

Machine learning enables identification of an alternative yeast galactose utilization pathway.

Proceedings of the National Academy of Sciences of the United States of America
How genomic differences contribute to phenotypic differences is a major question in biology. The recently characterized genomes, isolation environments, and qualitative patterns of growth on 122 sources and conditions of 1,154 strains from 1,049 fung...

Predicting chronic kidney disease progression with artificial intelligence.

BMC nephrology
BACKGROUND: The use of tools that allow estimation of the probability of progression of chronic kidney disease (CKD) to advanced stages has not yet achieved significant practical importance in clinical setting. This study aimed to develop and validat...

Heart patient health monitoring system using invasive and non-invasive measurement.

Scientific reports
The abnormal heart conduction, known as arrhythmia, can contribute to cardiac diseases that carry the risk of fatal consequences. Healthcare professionals typically use electrocardiogram (ECG) signals and certain preliminary tests to identify abnorma...

An individualized protein-based prognostic model to stratify pediatric patients with papillary thyroid carcinoma.

Nature communications
Pediatric papillary thyroid carcinomas (PPTCs) exhibit high inter-tumor heterogeneity and currently lack widely adopted recurrence risk stratification criteria. Hence, we propose a machine learning-based objective method to individually predict their...

Mandibular and dental measurements for sex determination using machine learning.

Scientific reports
The present study tested the combination of mandibular and dental dimensions for sex determination using machine learning. Lateral cephalograms and dental casts were used to obtain mandibular and mesio-distal permanent teeth dimensions, respectively....

Metabolomics facilitates differential diagnosis in common inherited retinal degenerations by exploring their profiles of serum metabolites.

Nature communications
The diagnosis of inherited retinal degeneration (IRD) is challenging owing to its phenotypic and genotypic complexity. Clinical information is important before a genetic diagnosis is made. Metabolomics studies the entire picture of bioproducts, which...

Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells.

Science (New York, N.Y.)
Chemical modulation of proteins enables a mechanistic understanding of biology and represents the foundation of most therapeutics. However, despite decades of research, 80% of the human proteome lacks functional ligands. Chemical proteomics has advan...