BACKGROUND: Adequate bowel preparation is crucial for effective colonoscopy, especially in elderly patients who face a high risk of inadequate preparation. This study develops and validates a machine learning model to predict bowel preparation adequa...
OBJECTIVE: This study aimed to construct a model based on machine learning to predict new HIV infections in HIV-negative men who have sex with men (MSM).
Diabetic kidney disease (DKD) is a serious healthcare dilemma. Nonetheless, the interplay between the functional capacity of gut microbiota and their host remains elusive for DKD. This study aims to elucidate the functional capability of gut microbio...
Selection of lead therapeutic molecules is often driven predominantly by pharmacological efficacy and safety. Candidate developability, such as biophysical properties that affect the formulation of the molecule into a product, is usually evaluated on...
Therapeutic monoclonal antibodies (mAbs) are a successful class of biologic drugs that are frequently selected from phage display libraries and transgenic mice that produce fully human antibodies. However, binding affinity to the correct epitope is n...
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
Artificial cells, nanomedicine, and biotechnology
Dec 1, 2025
Ageing significantly contributes to osteoarthritis (OA) and metabolic syndrome (MetS) pathogenesis, yet the underlying mechanisms remain unknown. This study aimed to identify ageing-related biomarkers in OA patients with MetS. OA and MetS datasets an...
European journal of psychotraumatology
Dec 1, 2025
The functional impairment resulting from CPTSD symptoms is enduring and far-reaching. Existing research has found that CPTSD symptoms are closely associated with childhood maltreatment; however, researchers debate whether CPTSD symptoms are predomin...
To retrospectively analyze the clinical characteristics of pediatric scrub typhus (ST) with meningoencephalitis (STME) and to construct and validate predictive models using machine learning.Clinical data were collected from 100 cases of pediatric STM...
European journal of psychotraumatology
Dec 1, 2025
Approximately 70% of individuals globally experience at least one traumatic event in their lifetimes, potentially leading to posttraumatic stress disorder (PTSD). Understanding the development of PTSD and devising effective prevention and treatment ...
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