About 30% of temporal lobe epilepsy (TLE) cases are negative on MRI, so quantitative diagnosis based on clinical symptoms becomes challenging. There is an urgent need for an accurate and reliable method to differentiate patients with MRI-negative TLE...
Therapeutic options for refractory depression are urgently needed. We conducted a deep brain stimulation (DBS) randomized controlled trial of the bed nucleus of the stria terminalis (BNST), an extended amygdala structure, and nucleus accumbens (NAc) ...
INTRODUCTION: High-flow nasal cannula (HFNC) is an important treatment option for acute hypoxic respiratory failure and can improve outcomes. However, patients on a prolonged duration of HFNC have worse clinical outcomes and increased mortality. It i...
World journal of microbiology & biotechnology
Nov 18, 2025
There is a growing concern about fungal infections and antifungal resistance among fungal species, underscoring the need for finding alternative treatments. Antifungal peptides (AFPs) are interesting and promising candidates for developing novel anti...
Environmental monitoring and assessment
Nov 18, 2025
The spatiotemporal evolution of water quality is fundamental for the management of water resources in long-distance water transfer projects (LWTPs). Due to the multidimensional and nonlinear characteristics of water quality monitoring data, a novel m...
This study examines the function of chromatin-remodeling genes (CRGs) in nasopharyngeal carcinoma (NPC), with an emphasis on their potential as prognostic and diagnostic biomarkers. We examined gene expression information collected from multiple data...
Patients with early-onset kidney cancer (EOKC) face a marked decline in prognosis after distant metastasis, yet the accuracy of current predictive methods remains limited. This study aims to develop a predictive model using multiple machine learning ...
To improve the intelligent and refined management level of power distribution systems in equipment operation and maintenance as well as emergency support, this work proposes an integrated "prediction-optimization" model that combines genetic algorith...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
Journal of chemical information and modeling
Nov 17, 2025
Data-driven modeling based on machine learning (ML) is becoming a central component of protein engineering workflows. This perspective presents the elements necessary to develop effective, reliable, and reproducible ML models, and a set of guidelines...
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