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Macular Degeneration

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Deep learning architectures analysis for age-related macular degeneration segmentation on optical coherence tomography scans.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVES: Aged people usually are more to be diagnosed with retinal diseases in developed countries. Retinal capillaries leakage into the retina swells and causes an acute vision loss, which is called age-related macular degeneration...

Deep Learning Automated Detection of Reticular Pseudodrusen from Fundus Autofluorescence Images or Color Fundus Photographs in AREDS2.

Ophthalmology
PURPOSE: To develop deep learning models for detecting reticular pseudodrusen (RPD) using fundus autofluorescence (FAF) images or, alternatively, color fundus photographs (CFP) in the context of age-related macular degeneration (AMD).

Predicting conversion to wet age-related macular degeneration using deep learning.

Nature medicine
Progression to exudative 'wet' age-related macular degeneration (exAMD) is a major cause of visual deterioration. In patients diagnosed with exAMD in one eye, we introduce an artificial intelligence (AI) system to predict progression to exAMD in the ...

Role of Deep Learning-Quantified Hyperreflective Foci for the Prediction of Geographic Atrophy Progression.

American journal of ophthalmology
PURPOSE: To quantitatively measure hyperreflective foci (HRF) during the progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) using deep learning (DL) and investigate the association with local and global growth ...

Evaluation of a deep learning system for the joint automated detection of diabetic retinopathy and age-related macular degeneration.

Acta ophthalmologica
PURPOSE: To validate the performance of a commercially available, CE-certified deep learning (DL) system, RetCAD v.1.3.0 (Thirona, Nijmegen, The Netherlands), for the joint automatic detection of diabetic retinopathy (DR) and age-related macular dege...

DualWMDR: Detecting epistatic interaction with dual screening and multifactor dimensionality reduction.

Human mutation
Detecting epistatic interaction is a typical way of identifying the genetic susceptibility of complex diseases. Multifactor dimensionality reduction (MDR) is a decent solution for epistasis detection. Existing MDR-based methods still suffer from high...

[Chances of Artificial Intelligence and Big Data for the Diagnosis and Treatment of Age-related Macular Degeneration].

Klinische Monatsblatter fur Augenheilkunde
Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) is an effective therapy of the neovascular form of this condition. Multimodal...

Automated detection and classification of early AMD biomarkers using deep learning.

Scientific reports
Age-related macular degeneration (AMD) affects millions of people and is a leading cause of blindness throughout the world. Ideally, affected individuals would be identified at an early stage before late sequelae such as outer retinal atrophy or exud...

Automatic segmentation of hyperreflective foci in OCT images.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: The leading cause of vision loss in the Western World is Age-related Macular Degeneration (AMD), but together with modern medicines, tracking the number of Hyperreflective Foci (HF) on Optical Coherence Tomography (OCT) imag...

Self-supervised iterative refinement learning for macular OCT volumetric data classification.

Computers in biology and medicine
We present self-supervised iterative refinement learning (SIRL) as a pipeline to improve a type of macular optical coherence tomography (OCT) volumetric image classification algorithms. In this type of algorithms, first, two-dimensional (2D) image cl...