AIMC Topic: MCF-7 Cells
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celldeath: A tool for detection of cell death in transmitted light microscopy images by deep learning-based visual recognition.
PloS one
Jun 24, 2021
Cell death experiments are routinely done in many labs around the world, these experiments are the backbone of many assays for drug development. Cell death detection is usually performed in many ways, and requires time and reagents. However, cell dea...
Prediction of Anticancer Peptides with High Efficacy and Low Toxicity by Hybrid Model Based on 3D Structure of Peptides.
International journal of molecular sciences
May 26, 2021
Recently, anticancer peptides (ACPs) have emerged as unique and promising therapeutic agents for cancer treatment compared with antibody and small molecule drugs. In addition to experimental methods of ACPs discovery, it is also necessary to develop ...
Exploring photoacoustic spectroscopy-based machine learning together with metabolomics to assess breast tumor progression in a xenograft model ex vivo.
Laboratory investigation; a journal of technical methods and pathology
Apr 19, 2021
In the current study, a breast tumor xenograft was established in athymic nude mice by subcutaneous injection of the MCF-7 cell line and assessed the tumor progression by photoacoustic spectroscopy combined with machine learning tools. The advancemen...
Analyzing protein dynamics from fluorescence intensity traces using unsupervised deep learning network.
Communications biology
Nov 12, 2020
We propose an unsupervised deep learning network to analyze the dynamics of membrane proteins from the fluorescence intensity traces. This system was trained in an unsupervised manner with the raw experimental time traces and synthesized ones, so nei...
A new diarylhexane and two new diarylpropanols from the roots of .
Natural product research
Sep 16, 2020
A new diarylhexane, kneglobularone B () and two new diarylpropanols, kneglobularols A - B () along with seven known compounds () were isolated and characterized from the roots of It is the first time to find arylpropyl quinone () and isoflavone () i...
Photoelectrochemical detection of circulating tumor cells based on aptamer conjugated CuO as signal probe.
Biosensors & bioelectronics
Dec 20, 2019
In this work, a sensitive and reliable photoelectrochemical (PEC) biosensor was proposed based on hexagonal carbon nitride tubes (HCNT) as photoactive material for detection of circulating tumor cells (CTCs). Magnetic FeO nanospheres (MNs) and CuO na...
System-level responses to cisplatin in pro-apoptotic stages of breast cancer MCF-7 cell line.
Computational biology and chemistry
Nov 2, 2019
Cisplatin ceases cell division and induces apoptosis in cancer cell lines. It is well established that cisplatin alters the expression of many genes involved in several cellular processes and pathways including transcription, p53 signaling pathway, a...
Phytochemical analysis and evaluation of the antioxidant and antiproliferative effects of Tucumã oil nanocapsules in breast adenocarcinoma cells (MCF-7).
Natural product research
Sep 5, 2019
In this work was to develop an inedited nanocapsule with tucumã oil (). The oil presents of phytosterols (squalene and β-sitosterol), --beta-carotene, acids oleic and palmitic. Antioxidant activity showed a good performance in DPPH and ABTS assays. T...
The optoelectronic microrobot: A versatile toolbox for micromanipulation.
Proceedings of the National Academy of Sciences of the United States of America
Jul 9, 2019
Microrobotics extends the reach of human-controlled machines to submillimeter dimensions. We introduce a microrobot that relies on optoelectronic tweezers (OET) that is straightforward to manufacture, can take nearly any desirable shape or form, and ...
An Intelligent DNA Nanorobot with Enhanced Protein Lysosomal Degradation of HER2.
Nano letters
Jun 5, 2019
DNA nanorobots have emerged as new tools for nanomedicine with the potential to ameliorate the delivery and anticancer efficacy of various drugs. DNA nanostructures have been considered one of the most promising nanocarriers. In the present study, we...
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