AIMC Topic: Membrane Proteins
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Mem-mEN: Predicting Multi-Functional Types of Membrane Proteins by Interpretable Elastic Nets.
IEEE/ACM transactions on computational biology and bioinformatics
Aug 28, 2015
Membrane proteins play important roles in various biological processes within organisms. Predicting the functional types of membrane proteins is indispensable to the characterization of membrane proteins. Recent studies have extended to predicting si...
Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion.
Molecular informatics
Jul 17, 2015
Malaria remains a dreadful disease by putting every year about 3.4 billion people at risk and resulting into mortality of 627 thousand people worldwide. Existing therapies based upon Quinines and Artemisinin-based combination therapies have started s...
Bioinformatics approach reveals systematic mechanism underlying lung adenocarcinoma.
Tumori
May 21, 2015
BACKGROUND: The purpose of this work was to explore the systematic molecular mechanism of lung adenocarcinoma and gain a deeper insight into it.
Humans
Software
Gene Expression Profiling
Peroxisome Proliferator-Activated Receptors
Lung Neoplasms
Signal Transduction
Adenocarcinoma of Lung
Protein Array Analysis
Adenocarcinoma
Collagen Type X
Gene Ontology
Computational Biology
Calcium
Receptor Cross-Talk
Gene Expression Regulation, Neoplastic
Membrane Proteins
A Machine Learning Approach to Explain Drug Selectivity to Soluble and Membrane Protein Targets.
Molecular informatics
Jan 8, 2015
Improved understanding of the forces that determine drug specificity to their targets is important for drug design and discovery, as well as for gaining knowledge about molecular recognition. Here, we present a machine learning approach that includes...
Deep Learning Reveals Liver MRI Features Associated With PNPLA3 I148M in Steatotic Liver Disease.
Liver international : official journal of the International Association for the Study of the Liver
Jul 1, 2025
BACKGROUND: Steatotic liver disease (SLD) is the most common liver disease worldwide, affecting 30% of the global population. It is strongly associated with the interplay of genetic and lifestyle-related risk factors. The genetic variant accounting f...
Phage display enables machine learning discovery of cancer antigen-specific TCRs.
Science advances
Jun 13, 2025
T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous and therapy-induced immune responses. Epitope recognition is mediated by the binding of the T cell receptor (TCR), and TCRs recognizing clinically relevant...
Machine learning identifies SRD5A3 as a propionate-related prognostic biomarker in triple-negative breast cancer.
Scientific reports
May 29, 2025
The increased risk of recurrence and metastasis are obstacles to treating TNBC. Propionate-related genes play an important role in tumor development and immune cell infiltration. The study was to identify the association between propionate-related ge...
AI-designed antibody candidates hit a crucial target.
Science (New York, N.Y.)
May 15, 2025
Companies find enticing drug leads that bind to tricky cell membrane proteins.
Boi-Ogi-To, a Traditional Japanese Kampo Medicine, Promotes Cellular Excretion of Chloride and Water by Activating Volume-Sensitive Outwardly Rectifying Anion Channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
May 15, 2025
The Japanese Kampo medicine Boi-ogi-to (BOT) is known as an effective therapeutic agent for edema and nephrosis by promoting the excretion of excess body fluids. Despite its empirical effectiveness, scientific evidence supporting its effectiveness re...
Designer artificial environments for membrane protein synthesis.
Nature communications
May 10, 2025
Protein synthesis in natural cells involves intricate interactions between chemical environments, protein-protein interactions, and protein machinery. Replicating such interactions in artificial and cell-free environments can control the precision of...
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