AIMC Topic: Metabolome

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Metabolomic profiling of plasma reveals differential disease severity markers in avian influenza A(H7N9) infection patients.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
OBJECTIVES: Avian influenza such as H7N9 is currently a major global public health risk, and at present, there is a lack of relevant diagnostic and treatment markers.

Comprehensive statistical and machine learning framework for identification of metabolomic biomarkers in breast cancer.

Metabolomics : Official journal of the Metabolomic Society
INTRODUCTION: Breast cancer is the most common cancer among women, with its burden increasing over the past decades. Early diagnosis significantly improves survival rates and reduces lethality. Innovative technologies are being developed for early de...

A plasma metabolome-derived model predicts severe liver outcomes of nonalcoholic fatty liver disease in the UK Biobank.

Diabetes, obesity & metabolism
AIMS: Severe liver disease (SLD) in nonalcoholic fatty liver disease (NAFLD) is often diagnosed late due to the long asymptomatic period of progressive fibrosis. We aimed to identify metabolomic profiles associated with SLD and develop a predictive m...

Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.

Frontiers in immunology
BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and therapies...

Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.

Metabolomics : Official journal of the Metabolomic Society
INTRODUCTION: There are significant challenges remain in accurately categorizing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients.

Deciphering microbial and metabolic influences in gastrointestinal diseases-unveiling their roles inĀ gastric cancer, colorectal cancer, and inflammatory bowel disease.

Journal of translational medicine
INTRODUCTION: Gastrointestinal disorders (GIDs) affect nearly 40% of the global population, with gut microbiome-metabolome interactions playing a crucial role in gastric cancer (GC), colorectal cancer (CRC), and inflammatory bowel disease (IBD). This...

GLIO-Select: Machine Learning-Based Feature Selection and Weighting of Tissue and Serum Proteomic and Metabolomic Data Uncovers Sex Differences in Glioblastoma.

International journal of molecular sciences
Glioblastoma (GBM) is a fatal brain cancer known for its rapid and aggressive growth, with some studies indicating that females may have better survival outcomes compared to males. While sex differences in GBM have been observed, the underlying biolo...

Transcripts and genomic intervals associated with variation in metabolite abundance in maize leaves under field conditions.

BMC genomics
Plants exhibit extensive environment-dependent intraspecific metabolic variation, which likely plays a role in determining variation in whole plant phenotypes. However, much of the work seeking to use natural variation to link genes and transcript's ...

Metabolomic signatures of pathogen suppression effect of Baltic eelgrass meadows in surrounding seawater.

The Science of the total environment
Organic molecules exuded into water column by marine organisms represent a significant portion of marine dissolved organic matter (DOM) that modulates biochemical interactions. Secreted allelochemicals have been suggested to be involved in regulation...