AIMC Topic: Metagenomics

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Global wastewater microbiome reveals core bacterial community and viral diversity with regional antibiotic resistance patterns.

mSystems
Municipal wastewater treatment plants (WWTPs) serve as global repositories for diverse and dynamic microbial communities, reflecting the complex interplay of human activities, environmental conditions, and public health challenges. Despite their impo...

Viral community succession during cadaver decomposition and its potential for estimating postmortem intervals.

Applied and environmental microbiology
UNLABELLED: Microbial communities play a vital role in cadaver decomposition and serve as reliable tools for postmortem interval (PMI) estimation. However, current research focuses primarily on bacterial/fungal communities, though viruses-as Earth's ...

Metagenomic research on the structural difference of plaque microbiome from different caries stages and the construction of a caries diagnostic model.

mSystems
Development of dental caries is a dynamic process; yet, there is limited knowledge on microbial differences at various stages of caries at higher resolution. To investigate the shifting microbiome profiles across different caries stages, 30 children ...

Gut microbiota and SCFAs improve the treatment efficacy of chemotherapy and immunotherapy in NSCLC.

NPJ biofilms and microbiomes
The role of gut dysbiosis in shaping immunotherapy responses is well-recognized, yet its effect on the therapeutic efficacy of chemotherapy and immunotherapy combinations remains poorly understood. We analyzed gut microbiota in non-small cell lung ca...

A critical review on the application of environmental DNA (eDNA) metagenomics in monitoring and assessing biological communities post marine oil spills.

The Science of the total environment
Oil spills pose a serious threat to marine communities, and there is an urgent need for an effective technique to monitor and assess the impacts on biological communities. While traditional methods with low sensitivity, being time-consuming and limit...

Application of image guided analyses to monitor fecal microbial composition and diversity in a human cohort.

Scientific reports
The critical role of gut microbiota in human health and disease has been increasingly illustrated over the past decades, with a significant amount of research demonstrating an unmet need for self-monitor of the fecal microbial composition in an easil...

Ensemble learning for microbiome-based caries diagnosis: multi-group modeling and biological interpretation from salivary and plaque metagenomic data.

BMC oral health
BACKGROUND: Oral microbiota is a major etiological factor in the development of dental caries. Next-generation sequencing techniques have been widely used, generating vast amounts of data which is underexplored. The advancement of artificial intellig...

Extensive novel diversity and phenotypic associations in the dromedary camel microbiome are revealed through deep metagenomics and machine learning.

PloS one
The dromedary camel, also known as one-humped camel or Arabian camel, is iconic and economically important to Arabian society. Its contemporary importance in commerce and transportation, along with the historical and modern use of its milk and meat p...

Machine learning-selected minimal features drive high-accuracy rule-based antibiotic susceptibility predictions for via metagenomic sequencing.

Microbiology spectrum
Antimicrobial resistance (AMR) represents a critical global health challenge, demanding rapid and accurate antimicrobial susceptibility testing (AST) to guide timely treatments. Traditional culture-based AST methods are slow, while existing whole-gen...

Gut microbiota alterations are linked to COVID-19 severity in North African and European populations.

NPJ biofilms and microbiomes
Although COVID-19 primarily affects the respiratory system, many patients experience gastrointestinal symptoms, suggesting a role for the gut microbiota in disease pathogenesis. To explore this, we performed shotgun metagenomic sequencing on stool sa...