AIMC Topic: Mice
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Alkaline phosphatase determines polyphosphate-induced mineralization in a cell-type independent manner.
Journal of bone and mineral metabolism
Oct 16, 2015
Polyphosphate [Poly(P)] has positive effects on osteoblast mineralization; however, the underlying mechanism remains unclear. In addition, it is unknown whether Poly(P) promotes mineralization in soft tissues. We investigated this by using various ce...
Firing rate dynamics in recurrent spiking neural networks with intrinsic and network heterogeneity.
Journal of computational neuroscience
Oct 9, 2015
Heterogeneity of neural attributes has recently gained a lot of attention and is increasing recognized as a crucial feature in neural processing. Despite its importance, this physiological feature has traditionally been neglected in theoretical studi...
Effect of earthworm active protein on fibroblast proliferation and its mechanism.
Pharmaceutical biology
Oct 7, 2015
CONTEXT: Earthworms have been used as a traditional medicine in China from thousands of years. In recent years, research has demonstrated that earthworm extracts might promote wound healing; however, its mechanism is still unknown.
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification.
Immunogenetics
Sep 29, 2015
A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound peptide is then presented ...
Computational Biology
Cluster Analysis
Databases, Protein
Models, Molecular
Peptide Fragments
Epitopes
Amino Acid Sequence
Binding Sites
Algorithms
Animals
Protein Binding
Mice
Humans
Neural Networks, Computer
Molecular Sequence Data
Sequence Homology, Amino Acid
Histocompatibility Antigens Class II
Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.
Pharmaceutical research
Sep 28, 2015
PURPOSE: Mouse efficacy studies are a critical hurdle to advance translational research of potential therapeutic compounds for many diseases. Although mouse liver microsomal (MLM) stability studies are not a perfect surrogate for in vivo studies of m...
Characterization and machine learning prediction of allele-specific DNA methylation.
Genomics
Sep 25, 2015
A large collection of Single Nucleotide Polymorphisms (SNPs) has been identified in the human genome. Currently, the epigenetic influences of SNPs on their neighboring CpG sites remain elusive. A growing body of evidence suggests that locus-specific ...
PathwaysWeb: a gene pathways API with directional interactions, expanded gene ontology, and versioning.
Bioinformatics (Oxford, England)
Sep 23, 2015
UNLABELLED: PathwaysWeb is a resource-based, well-documented web system that provides publicly available information on genes, biological pathways, Gene Ontology (GO) terms, gene-gene interaction networks (importantly, with the directionality of inte...
Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning.
Proceedings of the National Academy of Sciences of the United States of America
Sep 9, 2015
A lack of automated, quantitative, and accurate assessment of social behaviors in mammalian animal models has limited progress toward understanding mechanisms underlying social interactions and their disorders such as autism. Here we present a new in...
An Inversion Scheme for Hybrid Fluorescence Molecular Tomography Using a Fuzzy Inference System.
IEEE transactions on medical imaging
Sep 1, 2015
The imaging performance of fluorescence molecular tomography (FMT) improves when information from the underlying anatomy is incorporated into the inversion scheme, in the form of priors. The requirement for incorporation of priors has recently driven...
LncRNA-ID: Long non-coding RNA IDentification using balanced random forests.
Bioinformatics (Oxford, England)
Aug 26, 2015
MOTIVATION: Long non-coding RNAs (lncRNAs), which are non-coding RNAs of length above 200 nucleotides, play important biological functions such as gene expression regulation. To fully reveal the functions of lncRNAs, a fundamental step is to annotate...
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