Perfluorooctanoic acid (PFOA), a widely used industrial chemical, poses significant environmental and biological toxicity, particularly affecting reproductive health. This study aimed to integrate network toxicology, machine learning, and molecular d...
Pflugers Archiv : European journal of physiology
Jun 1, 2025
The renal thick ascending limb (TAL) plays a key role in water and ion homeostasis. Apical potassium secretion via the renal outer medullary potassium channel (ROMK) is essential for transepithelial sodium reabsorption via the furosemide-sensitive Na...
In the realm of cardiovascular medicine, medical imaging plays a crucial role in accurately classifying cardiac diseases and making precise diagnoses. However, the integration of data science techniques in this field presents significant challenges, ...
OBJECTIVE: In preclinical models of osteoarthritis (OA), histology is commonly used to evaluate joint remodeling. The current study introduces a deep learning driven histological analysis pipeline for the spatial evaluation of knee osteoarthritis (SE...
Mitochondria are central to cellular energy production and regulation, with their morphology tightly linked to functional performance. Precise analysis of mitochondrial ultrastructure is crucial for understanding cellular bioenergetics and pathology....
Rapid communications in mass spectrometry : RCM
May 30, 2025
Gancao Fuzi decoction (GCFZT) is a traditional Chinese formula, which has been commonly used in clinical practice to treat inflammatory diseases. However, the active substance of GCFZT in the treatment of inflammation is not fully clarified. In this ...
Biomedical physics & engineering express
May 28, 2025
Laser-induced thermal injury is a common form of skin damage in clinical treatment, and accurately assessing the extent of injury and treatment efficacy is crucial for patient recovery. In recent years, deep learning models have been increasingly app...
Chromatin and DNA modifications mediate the transcriptional activity of lineage-specifying enhancers, but recent work challenges the dogma that joint chromatin accessibility and DNA demethylation are prerequisites for transcription. To understand thi...
Brain computer interfaces (BCIs) require substantial cognitive flexibility to optimize control performance. Remarkably, learning this control is rapid, suggesting it might be mediated by neuroplasticity mechanisms operating on very short time scales....
Disgust, a primary negative emotion, plays a vital role in protecting organisms from intoxication and infection. In rodents, this emotion has been quantified by measuring the specific reactions elicited by exposure to unpleasant tastes. These reactio...
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