AIMC Topic: Mice
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Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.
Nature communications
Jun 18, 2025
Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed...
Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.
Science translational medicine
Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.
ACS nano
Jun 16, 2025
Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this work, utilizing anaerobic bacteria capable of seeking out hypoxic areas for flourishing, we constructed...
Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.
ACS applied materials & interfaces
Jun 16, 2025
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...
Enhancing R-loop prediction with high-throughput sequencing data.
NAR genomics and bioinformatics
Jun 11, 2025
R-loops are three-stranded RNA and DNA hybrid structures that often occur in the genome and play important roles in a variety of cellular processes from bacteria to mammals. Sequencing methods profiling R-loops genome-wide have revealed that they can...
Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex.
Nature neuroscience
Jun 6, 2025
From visual perception to language, sensory stimuli change their meaning depending on previous experience. Recurrent neural dynamics can interpret stimuli based on externally cued context, but it is unknown whether they can compute and employ interna...
Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping.
ACS nano
Jun 4, 2025
Current clinical treatment of pulmonary diseases requires an advanced three-dimensional (3D) pathological atlas of the microenvironment, particularly the trachea, which is predominantly affected by lung disorders. In this study, the gridded cyclodext...
Deep learning based rapid X-ray fluorescence signal extraction and image reconstruction for preclinical benchtop X-ray fluorescence computed tomography applications.
Scientific reports
Jun 4, 2025
Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (...
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Nature communications
Jun 4, 2025
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Identifying a gene signature for age-related hearing loss through machine learning and revealing the effect of the CTSS on the mice cochlea.
Biogerontology
Jun 3, 2025
Age-related hearing loss (ARHL) is one of the most common health conditions among the elderly population. This study used machine learning to screen for a gene signature to predicts ARHL. Four ARHL mice cochlear transcriptome datasets and the mRNA se...
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