- Herbal Pair (SEHP) is one of the classic Chinese herbal formulas for treating Alzheimer's disease (AD), but its complex chemical composition renders traditional analytical methods inefficient. Retention time (RT) provides complementary information ...
Proceedings of the National Academy of Sciences of the United States of America
Dec 10, 2025
Social information processing involves coordinated neural activity across distributed brain circuits, with the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) playing pivotal roles. However, whether these regions employ distinct coding...
Bacterial-mediated drug delivery has emerged as a promising strategy for disease treatment, leveraging bacteria's innate ability to penetrate biological barriers and target diseased tissues. However, existing bacteria-nanoparticle hybrid systems ofte...
Neuronal ensemble activity, including coordinated and oscillatory patterns, exhibits hallmarks of nonequilibrium systems with time-asymmetric trajectories to maintain their organization. However, assessing time asymmetry from neuronal spiking activit...
Despite decades of research, the successful clinical translation of intravenously administered nanomedicines is underwhelming. One significant barrier to progress is the opsonization and rapid clearance from the bloodstream due to protein corona form...
The human immune system has evolved to interact with various commensal and pathogenic bacteria in intricate and nuanced ways. While the diversity of bacteria presents fundamental challenges in understanding immune-microbe interactions, it also offers...
High-spatial-resolution mass spectrometry imaging (MSI) visualizes molecular distributions in tissues and cells. However, achieving higher spatial resolution typically necessitates smaller pixel dimensions and an increased number of pixels, leading t...
Cryopreservation of spermatozoa can be used as a cost-effective way of preserving the ever-increasing number of genetically modified mouse lines. Nevertheless, discontinuing the breeding of a line or strain is only warranted after the quality control...
BACKGROUND: Hepatic ischemia-reperfusion injury (HIRI) represents the leading cause of postoperative liver dysfunction and failure. Ammonia-induced cell death (ACD), defined by lysosomal and mitochondrial disruption due to intracellular ammonia accum...
The purpose of this work was to formulate and characterize pH-sensitive, surfactant-based nanomicelles for the targeted delivery of Oxaliplatin to breast cancer cells. A secondary aim was to utilize machine learning (ML) models to interpolate and dis...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.