AIMC Topic: Heroin

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Supervised and unsupervised learning reveal heroin-induced impairments in astrocyte structural plasticity.

Science advances Apr 30, 2025
Astrocytes regulate synaptic activity across large brain territories via their complex, interconnected morphology. Emerging evidence supports the involvement of astrocytes in shaping relapse to opioid use through morphological rearrangements in the n...
Animals Male Neuronal Plasticity Heroin Supervised Machine Learning Nucleus Accumbens Unsupervised Machine Learning Astrocytes
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Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model.

Biological psychiatry Dec 25, 2024
BACKGROUND: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior ...
Prefrontal Cortex Rats Male Transcriptome Heroin Humans Adult Heroin Dependence Rats, Sprague-Dawley Machine Learning Animals Drug-Seeking Behavior Disease Models, Animal
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The Detection of Opioid Misuse and Heroin Use From Paramedic Response Documentation: Machine Learning for Improved Surveillance.

Journal of medical Internet research Jan 3, 2020
BACKGROUND: Timely, precise, and localized surveillance of nonfatal events is needed to improve response and prevention of opioid-related problems in an evolving opioid crisis in the United States. Records of naloxone administration found in prehospi...
Emergency Medical Services Analgesics, Opioid Allied Health Personnel Male Drug Overdose Heroin Machine Learning Female Humans
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Using natural language processing of clinical text to enhance identification of opioid-related overdoses in electronic health records data.

Pharmacoepidemiology and drug safety Jun 19, 2019
PURPOSE: To enhance automated methods for accurately identifying opioid-related overdoses and classifying types of overdose using electronic health record (EHR) databases.
Heroin Washington Self-Injurious Behavior Risk Datasets as Topic Drug Overdose Sensitivity and Specificity Predictive Value of Tests Analgesics, Opioid Humans Opioid-Related Disorders Electronic Health Records Natural Language Processing
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A computational strategy for finding novel targets and therapeutic compounds for opioid dependence.

PloS one Nov 7, 2018
Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and ...
Neurons Opioid-Related Disorders Corpus Striatum Gene Ontology Machine Learning Gene Expression Regulation Small Molecule Libraries Analgesics, Opioid Animals Heroin Morphine Mice
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Exchanging expertise and constructing boundaries: The development of a transnational knowledge network around heroin-assisted treatment.

The International journal on drug policy Dec 17, 2015
Over the last 20 years, supervised injectable and inhalable heroin prescribing has been developed, tested and in some cases introduced as a second line treatment for limited groups of entrenched heroin users in a number of European countries and Cana...
Interdisciplinary Communication Analgesics, Opioid Treatment Outcome Heroin Cooperative Behavior Administration, Inhalation Injections, Intravenous Knowledge Bases Heroin Dependence Public Opinion Humans International Cooperation Evidence-Based Medicine Behavior, Addictive Qualitative Research Stakeholder Participation Drug Users
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