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Microfluidics

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Stretchable pumps for soft machines.

Nature
Machines made of soft materials bridge life sciences and engineering. Advances in soft materials have led to skin-like sensors and muscle-like actuators for soft robots and wearable devices. Flexible or stretchable counterparts of most key mechatroni...

Microwheels on Microroads: Enhanced Translation on Topographic Surfaces.

Science robotics
Microbot locomotion is challenging because of the reversible nature of microscale fluid flow, a limitation that can be overcome by breaking flowfield symmetry with a nearby surface. We have used this strategy with rotating wheel-shaped microbots, μwh...

The optoelectronic microrobot: A versatile toolbox for micromanipulation.

Proceedings of the National Academy of Sciences of the United States of America
Microrobotics extends the reach of human-controlled machines to submillimeter dimensions. We introduce a microrobot that relies on optoelectronic tweezers (OET) that is straightforward to manufacture, can take nearly any desirable shape or form, and ...

3D Fabrication of Fully Iron Magnetic Microrobots.

Small (Weinheim an der Bergstrasse, Germany)
Biocompatibility and high responsiveness to magnetic fields are fundamental requisites to translate magnetic small-scale robots into clinical applications. The magnetic element iron exhibits the highest saturation magnetization and magnetic susceptib...

Deep Learning with Microfluidics for Biotechnology.

Trends in biotechnology
Advances in high-throughput and multiplexed microfluidics have rewarded biotechnology researchers with vast amounts of data but not necessarily the ability to analyze complex data effectively. Over the past few years, deep artificial neural networks ...

Kernel-Based Microfluidic Constriction Assay for Tumor Sample Identification.

ACS sensors
A high-throughput multiconstriction microfluidic channels device can distinguish human breast cancer cell lines (MDA-MB-231, HCC-1806, MCF-7) from immortalized breast cells (MCF-10A) with a confidence level of ∼81-85% at a rate of 50-70 cells/min bas...

Autonomous Magnetic Microrobots by Navigating Gates for Multiple Biomolecules Delivery.

Small (Weinheim an der Bergstrasse, Germany)
The precise delivery of biofunctionalized matters is of great interest from the fundamental and applied viewpoints. In spite of significant progress achieved during the last decade, a parallel and automated isolation and manipulation of rare analyte,...

Label-free detection of cellular drug responses by high-throughput bright-field imaging and machine learning.

Scientific reports
In the last decade, high-content screening based on multivariate single-cell imaging has been proven effective in drug discovery to evaluate drug-induced phenotypic variations. Unfortunately, this method inherently requires fluorescent labeling which...

Cytopathological image analysis using deep-learning networks in microfluidic microscopy.

Journal of the Optical Society of America. A, Optics, image science, and vision
Cytopathologic testing is one of the most critical steps in the diagnosis of diseases, including cancer. However, the task is laborious and demands skill. Associated high cost and low throughput drew considerable interest in automating the testing pr...