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Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis.

Arthritis research & therapy
BACKGROUND: The modified Rodnan skin score (mRSS), a measure of systemic sclerosis (SSc) skin thickness, is agnostic to inflammation and vasculopathy. Previously, we demonstrated the potential of neural network-based digital pathology applied to SSc ...

Predicting the efficacy of microwave ablation of benign thyroid nodules from ultrasound images using deep convolutional neural networks.

BMC medical informatics and decision making
BACKGROUND: Thyroid nodules are frequent in clinical settings, and their diagnosis in adults is growing, with some persons experiencing symptoms. Ultrasound-guided thermal ablation can shrink nodules and alleviate discomfort. Because the degree and r...

Predicting metabolic dysfunction associated steatotic liver disease using explainable machine learning methods.

Scientific reports
Early and accurate identification of patients at high risk of metabolic dysfunction-associated steatotic liver disease (MASLD) is critical to prevent and improve prognosis potentially. We aimed to develop and validate an explainable prediction model ...

Leveraging machine learning in precision medicine to unveil organochlorine pesticides as predictive biomarkers for thyroid dysfunction.

Scientific reports
Exposure to organochlorine pesticides (OCPs) poses significant health risks, including cancer, endocrine dysregulation, neurological disorders, and reproductive disruption. This study investigates the association between OCP exposure and thyroid dist...

Predicting PD-L1 status in NSCLC patients using deep learning radiomics based on CT images.

Scientific reports
Radiomics refers to the utilization of automated or semi-automated techniques to extract and analyze numerous quantitative features from medical images, such as computerized tomography (CT) or magnetic resonance imaging (MRI) scans. This study aims t...

Oxidative Stress Markers and Prediction of Severity With a Machine Learning Approach in Hospitalized Patients With COVID-19 and Severe Lung Disease: Observational, Retrospective, Single-Center Feasibility Study.

JMIR formative research
BACKGROUND: Serious pulmonary pathologies of infectious, viral, or bacterial origin are accompanied by inflammation and an increase in oxidative stress (OS). In these situations, biological measurements of OS are technically difficult to obtain, and ...

Clinical-level screening of sleep apnea syndrome with single-lead ECG alone is achievable using machine learning with appropriate time windows.

Sleep & breathing = Schlaf & Atmung
PURPOSE: To establish a simple and noninvasive screening test for sleep apnea (SA) that imposes less burden on potential patients. The specific objective of this study was to verify the effectiveness of past and future single-lead electrocardiogram (...

Detecting arousals and sleep from respiratory inductance plethysmography.

Sleep & breathing = Schlaf & Atmung
PURPOSE: Accurately identifying sleep states (REM, NREM, and Wake) and brief awakenings (arousals) is essential for diagnosing sleep disorders. Polysomnography (PSG) is the gold standard for such assessments but is costly and requires overnight monit...

Development of a Machine Learning Algorithm to Predict Abnormalities in Serum Phosphate in a Large Oncology Cohort.

JCO clinical cancer informatics
PURPOSE: Serum phosphate is commonly measured in oncology patients because of the relationship between oncologic conditions and treatments with abnormal phosphate. All patients attending our institution, a large specialist oncology center, have a sta...

Machine Learning Models of Early Longitudinal Toxicity Trajectories Predict Cetuximab Concentration and Metastatic Colorectal Cancer Survival in the Canadian Cancer Trials Group/AGITG CO.17/20 Trials.

JCO clinical cancer informatics
PURPOSE: Cetuximab (CET), targeting the epidermal growth factor receptor, is a systemic treatment option for patients with colorectal cancer. One known predictive factor for CET efficacy is the presence of CET-related rash; other putative toxicity fa...