BACKGROUND: Rheumatoid arthritis (RA), particularly seronegative disease, is difficult to diagnose early, which can delay treatment initiation. This study aims to develop a binary DNA methylation (DNAm)-based algorithm to diagnose RA.
BACKGROUND: It remains unclear whether certain individuals with type 2 diabetes (T2D) derive greater cardiovascular benefit from GLP-1 receptor agonists (GLP-1RAs). Here, we integrate individual-level data from cardiovascular outcome trials (CVOTs) a...
This study investigates how different forms of literacy shape trust in medical AI and its transfer in healthcare contexts. Based on a survey of 1,250 participants, three findings emerge. First, digital literacy and AI literacy exert opposite influenc...
BACKGROUND: Rising osteoporosis prevalence among elderly populations and limitations of current single-factor screening methods necessitate development of comprehensive multi-dimensional risk prediction models.
BACKGROUND: Insomnia is a significant independent risk factor for depression and suicidality. However, these conditions often go undetected, particularly in individuals presenting with sleep complaints. This study aimed to develop and validate machin...
BACKGROUND: The clinical significance and contribution of the lipid profile in atherosclerosis are well established. However, further investigation is needed in stroke patients, particularly regarding apolipoprotein B100 (ApoB100), a novel non-tradit...
BACKGROUND: Accurate preoperative T and TNM staging of clear cell renal cell carcinoma (ccRCC) is crucial for diagnosis and treatment, but these assessments often depend on subjective radiologist judgment, leading to interobserver variability. This s...
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Oct 17, 2025
BACKGROUND: Previous studies have indicated a correlation between the glycosylated hemoglobin index (HGI) and the prognosis of patients with sepsis. However, the impact of its dynamic fluctuations on patient outcomes remains insufficiently explored. ...
BACKGROUND: Progressive supranuclear palsy (PSP) is typically characterized by vertical supranuclear gaze palsy and early falls, referred to as Richardson's syndrome (PSP-RS). Other presentations include postural instability (PSP-PI), Parkinsonism (P...
Severe COVID-19 often progresses to critical illness, requiring accurate prognostic biomarkers. Lactate-to-albumin ratio (LAR) has been proposed as a novel indicator to estimate the likelihood of death. Using data from the MIMIC database, this retros...
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