AIMC Topic: Middle Aged

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Cingulate atrophy as a shared structural basis for cognitive and functional brain impairments in GAD, PD, and OCD: Links to shared gene expression and treatment implications.

Journal of affective disorders
BACKGROUND: Structural brain deficits associated with generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD) have been documented, but their integration within a unified framework remains unexplored. This stu...

Discrimination of urine infrared spectral biomarkers for early-stage chronic kidney disease patients using attenuated total reflectance fourier transform infrared spectrometry.

Clinica chimica acta; international journal of clinical chemistry
Chronic Kidney Disease (CKD) is a highly prevalent non-communicable disorder lacking a gold standard method for diagnosis. Early-stage CKD remains undiagnosed and untreated leading to the disease progression. The study aimed to discriminate urine sam...

Gut microbiota predictive of the efficacy of consolidation immunotherapy and chemoradiotherapy toxicity in lung cancer.

Med (New York, N.Y.)
BACKGROUND: Gut microbiota (GM) predict responses to immune checkpoint inhibitors (ICIs) in patients with advanced lung cancer. However, its role in patients with locally advanced lung cancer undergoing chemoradiotherapy (CRT) combined with consolida...

Computational pathology approach for assessment of prognosis and immunotherapy response in pan-gastrointestinal cancer.

Journal of translational medicine
BACKGROUND: Current cancer staging methods cannot accurately predict survival outcomes and therapeutic benefits in cancer patients. Digital pathomics, a rapidly evolving field, holds significant potential to revolutionize disease evaluation.

Multimodal deep learning model for prediction of breast cancer recurrence risk and correlation with oncotype DX.

Breast cancer research : BCR
BACKGROUND: Proper stratification of recurrence risk in breast cancer is crucial for guiding treatment decisions. This study aims to predict the recurrence risk of breast cancer patients using a multimodal deep learning model that integrates multiple...

Development and validation of artificial intelligence models for automated periodontitis staging and grading using panoramic radiographs.

BMC oral health
BACKGROUND: Periodontal diseases are common chronic conditions that can lead to tooth loss and systemic complications if not diagnosed and treated promptly. The 2017 classification by the American Academy of Periodontology highlights the need for eff...

Statistical and machine-learning assessment of attitudinal, knowledge, and perceptual factors on diabetes awareness in Kuwait.

BMC medical informatics and decision making
OBJECTIVES: The primary objective was to identify and analyze the factors that impact diabetes awareness and perception among diabetic and non-diabetic participants. The study also sought to assess the effectiveness of current health awareness progra...

Machine learning model development and validation using SHAP: predicting 28-day mortality risk in pulmonary fibrosis patients.

BMC medical informatics and decision making
BACKGROUND: Early prediction of mortality risk within 28 days of admission is crucial for personalized treatment in patients with pulmonary fibrosis (PF). This study aims to develop a predictive model for 28-day mortality risk in PF patients using in...

Prevalence and factors associated with HIV drug resistance among adult persons living with HIV/AIDS in nine countries of Sub-Saharan Africa using population-based HIV impact assessments: 2015-2019.

BMC public health
INTRODUCTION: HIV drug resistance (HIVDR) remains a significant challenge in sub-Saharan Africa (SSA) due to limited effective Treatment and healthcare resources vary. Using the first widely available HIVDR surveillance data in SSA, we calculated the...