Mitochondria, Heart

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Unveiling mitochondrial-targeting compounds in Qishenyiqi dropping pills for heart failure treatment: An integrative UHPLC-QTOF MS and high-content imaging strategy.

Journal of pharmaceutical and biomedical analysis Apr 23, 2025
Mitochondrial dysfunction, a central pathogenic driver of heart failure (HF), underscores the therapeutic imperative to preserve mitochondrial homeostasis. Qishenyiqi dropping pills (QSYQ), a clinically validated traditional Chinese formulation, exhi...
Humans Animals Mice Mass Spectrometry Drugs, Chinese Herbal Membrane Potential, Mitochondrial Mitochondria Heart Failure Chromatography, High Pressure Liquid Adenosine Triphosphate NIH 3T3 Cells Mitochondria, Heart
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Machine-learning to stratify diabetic patients using novel cardiac biomarkers and integrative genomics.

Cardiovascular diabetology Jun 11, 2019
BACKGROUND: Diabetes mellitus is a chronic disease that impacts an increasing percentage of people each year. Among its comorbidities, diabetics are two to four times more likely to develop cardiovascular diseases. While HbA1c remains the primary dia...
Humans Prognosis Female Risk Factors Male Middle Aged Risk Assessment Disease Progression Diabetes Mellitus, Type 2 Genomics Genetic Predisposition to Disease Polymorphism, Single Nucleotide Epigenesis, Genetic Models, Genetic Support Vector Machine DNA Methylation Glycated Hemoglobin Genetic Markers DNA, Mitochondrial CpG Islands Systems Integration Mitochondria, Heart Diabetic Cardiomyopathies
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[The research on protective effect of penehyclidine hydrochloride in rats with myocardial ischemia/reperfusion injury].

Zhonghua wei zhong bing ji jiu yi xue Dec 1, 2015
OBJECTIVE: To compare the protective effect of different dose of penehyclidine hydrochloride (PHC) in rats with myocardial ischemia/reperfusion (I/R) injury.
Animals Male Rats, Wistar Rats Myocardium Myocardial Reperfusion Injury Myocytes, Cardiac L-Lactate Dehydrogenase Furans Random Allocation Cardiotonic Agents Creatine Kinase, MB Form Mitochondria, Heart Quinuclidines
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