AIMC Topic: Molecular Targeted Therapy
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Linking rare and common disease: mapping clinical disease-phenotypes to ontologies in therapeutic target validation.
Journal of biomedical semantics
Mar 23, 2016
BACKGROUND: The Centre for Therapeutic Target Validation (CTTV - https://www.targetvalidation.org/) was established to generate therapeutic target evidence from genome-scale experiments and analyses. CTTV aims to support the validity of therapeutic t...
A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.
Journal of bioinformatics and computational biology
Oct 27, 2015
The blood-brain barrier (BBB), a highly selective barrier between central nervous system (CNS) and the blood stream, restricts and regulates the penetration of compounds from the blood into the brain. Drugs that affect the CNS interact with the BBB p...
ATP Binding Cassette Transporter, Subfamily B, Member 1
Drug Evaluation, Preclinical
Central Nervous System Agents
Permeability
Plants, Medicinal
Molecular Targeted Therapy
Models, Theoretical
Support Vector Machine
Medicine, Chinese Traditional
Reproducibility of Results
Blood-Brain Barrier
Humans
Algorithms
Nanorobots: Changing Trends in Cancer Therapy.
The journal of contemporary dental practice
Sep 1, 2015
Exploring the relationship between hub proteins and drug targets based on GO and intrinsic disorder.
Computational biology and chemistry
Mar 23, 2015
Protein-protein interactions (PPIs) play essential roles in many biological processes. In protein-protein interaction networks, hubs involve in numbers of PPIs and may constitute an important source of drug targets. The intrinsic disorder proteins (I...
Active-learning strategies in computer-assisted drug discovery.
Drug discovery today
Dec 9, 2014
High-throughput compound screening is time and resource consuming, and considerable effort is invested into screening compound libraries, profiling, and selecting the most promising candidates for further testing. Active-learning methods assist the s...
Medical management of pancreatic cancer: from personalization to broadening treatment strategies.
Cancer treatment reviews
Jul 1, 2025
Pancreatic ductal adenocarcinoma (PDAC) is one of the most heterogeneous and deadly cancers. This review examines recently implemented strategies to integrate predictive tools and targeted therapies to improve treatments personalization and patient o...
Editorial: New Target for Skin Cancer.
Experimental dermatology
Jun 1, 2025
Skin cancer encompasses a diverse spectrum of malignancies with increasing global incidence and persistent clinical challenges. Despite advances in therapies such as immune checkpoint inhibitors and targeted agents, many patients-especially those wit...
Exploring therapeutic and diagnostic potential of cysteine cathepsin as targets for cancer therapy with nanomedicine.
International journal of biological macromolecules
Jun 1, 2025
Cysteine cathepsins have been discovered to be substantially expressed in multiple types of cancer. They play a key role in the progression and growth of these cancers, rendering them appealing targets for nanoscale delivery and noninvasive diagnosti...
Inside a Metastatic Fracture: Molecular Bases and New Potential Therapeutic Targets.
Cancer medicine
May 1, 2025
INTRODUCTION: Bone metastases and pathological fractures significantly impact the prognosis and quality of life in cancer patients. However, clinical and radiological features alone have been shown to fail to predict skeletal related events of a bone...
Biologically Enhanced Machine Learning Model to uncover Novel Gene-Drug Targets for Alzheimer's Disease.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2025
Given the complexity and multifactorial nature of Alzheimer's disease, investigating potential drug-gene targets is imperative for developing effective therapies and advancing our understanding of the underlying mechanisms driving the disease. We pre...
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