The advancements of information technology and related processing techniques have created a fertile base for progress in many scientific fields and industries. In the fields of drug discovery and development, machine learning techniques have been use...
Small non-coding RNAs (ncRNAs) are short non-coding sequences involved in gene regulation in many biological processes and diseases. The lack of a complete comprehension of their biological functionality, especially in a genome-wide scenario, has dem...
Range verification in proton therapy is a critical quality assurance task. We studied the feasibility of online range verification based on proton-induced acoustic signals, using a bidirectional long-short-term-memory recurrent neural network and var...
We present a method for assembling directed networks given a prescribed bi-degree (in- and out-degree) sequence. This method utilises permutations of initial adjacency matrix assemblies that conform to the prescribed in-degree sequence, yet violate t...
BACKGROUND: Currently there is an ever increasing interest in Lu-177 targeted radionuclide therapies, which target neuro-endocrine and prostate tumours. For a patient-specific treatment, an individual dosimetry based on SPECT/CT imaging is necessary....
The aim of dose calculation algorithm research is to improve the calculation accuracy while maximizing the calculation efficiency. In this study, the three-dimensional distribution of total energy release per unit mass (TERMA) and the electron densit...
Journal of chemical information and modeling
Oct 13, 2020
The identification of synthetic routes that end with the desired product is considered an inherently time-consuming process that is largely dependent on expert knowledge regarding a limited proportion of the entire reaction space. At present, emergin...
The intra-axonal water exchange time (τ), a parameter associated with axonal permeability, could be an important biomarker for understanding and treating demyelinating pathologies such as Multiple Sclerosis. Diffusion-Weighted MRI (DW-MRI) is sensiti...
European journal of nuclear medicine and molecular imaging
Sep 1, 2020
PURPOSE: In the era of precision medicine, patient-specific dose calculation using Monte Carlo (MC) simulations is deemed the gold standard technique for risk-benefit analysis of radiation hazards and correlation with patient outcome. Hence, we propo...
The primary cone-beam computed tomography (CBCT) imaging beam scatters inside the patient and produces a contaminating photon fluence that is registered by the detector. Scattered photons cause artifacts in the image reconstruction, and are partially...
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