AIMC Topic: Nanoparticles

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NIR-II AIEgen with high photothermal efficiency for mild PTT: Optimized natural killer cell spatial distribution for boosted immune response.

Biomaterials
Organic photothermal agents (PTAs) with high photothermal conversion efficiency (PCE) and biocompatibility are ideal for mild photothermal therapy (PTT), which can selectively eliminate tumor cells and elicit an active immune response. However, the c...

The role of machine learning in predicting titanium dioxide nanoparticles induced pulmonary pathology using transcriptomic biomarkers.

Journal of hazardous materials
This study explores the application of machine learning (ML) in identifying transcriptomic changes associated with pulmonary pathologies induced by titanium dioxide nanoparticles (TiO-NPs). Such an approach significantly contributes to understanding ...

Cell Response to Nanoplastics and Their Carrier Effects Tracked Real-Timely with Machine Learning-Driven Smart Surface-Enhanced Raman Spectroscopy Slides.

Analytical chemistry
Research on nanoplastic (NP) toxicity and their "carrier effects" on human health remains nascent, especially for real-time, in situ monitoring of metabolic reactions in live cells. Herein, we developed smart surface-enhanced Raman spectroscopy (SERS...

Biofilm-mediated infections; novel therapeutic approaches and harnessing artificial intelligence for early detection and treatment of biofilm-associated infections.

Microbial pathogenesis
A biofilm is a group of bacteria that have self-produced a matrix and are grouped together in a dense population. By resisting the host's immune system's phagocytosis process and attacking with anti-microbial chemicals such as reactive oxygen and nit...

Utilization of machine learning approach for production of optimized PLGA nanoparticles for drug delivery applications.

Scientific reports
This study investigates utilization of machine learning for the regression task of predicting the size of PLGA (Poly lactic-co-glycolic acid) nanoparticles. Various inputs including category and numeric were considered for building the model to predi...

AI-driven innovations in smart multifunctional nanocarriers for drug and gene delivery: A mini-review.

Critical reviews in oncology/hematology
The convergence of artificial intelligence (AI) and nanomedicine has revolutionized the design of smart multifunctional nanocarriers (SMNs) for drug and gene delivery, offering unprecedented precision, efficiency, and personalization in therapeutic a...

Harnessing Computational Strategies to Overcome Challenges in mRNA Vaccines.

Physiology (Bethesda, Md.)
In recent years, the introduction of mRNA vaccines for SARS-CoV2 and respiratory syncytial virus (RSV) has highlighted the success of the mRNA technology platform. Designing mRNA sequences involves multiple components and requires balancing several p...

Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.

ACS nano
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...

Comparative immobilization of 30 PFAS mixtures onto biochar, clay, nanoparticle, and polymer derived engineered adsorbents: Machine learning insights into carbon chain length and removal mechanism.

Journal of hazardous materials
Per- and polyfluoroalkyl substances (PFAS) are a group of fluorinated chemicals that cause potential risk in PFAS-impacted soil and water. The adsorption efficiency of 30 PFAS mixtures using different adsorbents in environmentally relevant concentrat...

Optimizing thermal dose prediction in nanoparticle-mediated photothermal therapy using a convolutional neural network-based model.

Journal of thermal biology
Nanoparticle-mediated photothermal therapy (NMPTT) is an up-and-coming targeted cancer treatment. Here, nanoparticles are used to convert near-infrared light into localized heat that can kill tumour cells while sparing surrounding healthy tissue. Nev...