AIMC Topic: Necroptosis

Clear Filters Showing 11 to 12 of 12 articles

Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor.

Nature communications
The retrieval of hit/lead compounds with novel scaffolds during early drug development is an important but challenging task. Various generative models have been proposed to create drug-like molecules. However, the capacity of these generative models ...

Establishment and Validation of the Novel Necroptosis-related Genes for Predicting Stemness and Immunity of Hepatocellular Carcinoma Machine-learning Algorithm.

Combinatorial chemistry & high throughput screening
BACKGROUND: Necroptosis, a recently identified mechanism of programmed cell death, exerts significant influence on various aspects of cancer biology, including tumor cell proliferation, stemness, metastasis, and immunosuppression. However, the role o...