AIMC Topic: Neoplasms

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Noise-Consistent Hypergraph Autoencoder Based on Contrastive Learning for Cancer ceRNA Association Prediction in Complex Biological Regulatory Networks.

Journal of chemical information and modeling Jun 12, 2025
Competitive endogenous RNA (ceRNA) regulatory networks (CENA) have advanced our understanding of noncoding RNAs' roles in complex diseases, providing a theoretical basis for disease mechanisms. Existing ceRNA-disease association prediction methods ar...
Computational Biology Neoplasms Autoencoder Gene Regulatory Networks Humans RNA, Competitive Endogenous Machine Learning
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Explainable one-class feature extraction by adaptive resonance for anomaly detection in quality assurance.

PloS one Jun 10, 2025
In this study, we address the inherent challenges in radiotherapy (RT) plan quality assessment (QA). RT, a prevalent cancer treatment, utilizes high-energy beams to target tumors while sparing adjacent healthy tissues. Typically, an RT plan is refine...
Quality Assurance, Health Care Neoplasms Radiotherapy Planning, Computer-Assisted Humans Machine Learning Algorithms Neural Networks, Computer
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The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update.

Expert opinion on drug discovery Jun 5, 2025
INTRODUCTION: The landscape of drug discovery is rapidly evolving, with natural products (NPs) playing a pivotal role in the development of novel therapeutics. Despite their historical significance, challenges persist in fully harnessing their potent...
Humans Artificial Intelligence High-Throughput Screening Assays Drug Development Molecular Targeted Therapy Animals Biological Products Immunoconjugates Neoplasms Drug Discovery Computational Biology
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MFDSMC: Accurate Identification of Cancer-Driver Synonymous Mutations Using Multiperspective Feature Representation Learning.

Journal of chemical information and modeling Jun 5, 2025
Synonymous mutations do not change amino acid sequences, but they can drive cancer by influencing splicing, mRNA structure, translation efficiency, and other molecular mechanisms. Although driver synonymous mutations are significantly outnumbered by ...
Humans Computational Biology Mutation Silent Mutation Machine Learning Neoplasms
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GNNs surpass transformers in tumor medical image segmentation.

Scientific reports Jun 5, 2025
To assess the suitability of Transformer-based architectures for medical image segmentation and investigate the potential advantages of Graph Neural Networks (GNNs) in this domain. We analyze the limitations of the Transformer, which models medical i...
Image Processing, Computer-Assisted Algorithms Neoplasms Humans Neural Networks, Computer
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GNNMutation: a heterogeneous graph-based framework for cancer detection.

BMC bioinformatics Jun 4, 2025
BACKGROUND: When genes are translated into proteins, mutations in the gene sequence can lead to changes in protein structure and function as well as in the interactions between proteins. These changes can disrupt cell function and contribute to the d...
Mutation Exome Sequencing Neoplasms Computational Biology Neural Networks, Computer Humans Algorithms
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Current AI technologies in cancer diagnostics and treatment.

Molecular cancer Jun 2, 2025
Cancer continues to be a significant international health issue, which demands the invention of new methods for early detection, precise diagnoses, and personalized treatments. Artificial intelligence (AI) has rapidly become a groundbreaking componen...
Genomics Precision Medicine Biomarkers, Tumor Humans Neoplasms Artificial Intelligence
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Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid cancer treated with immune checkpoint inhibitors.

Journal for immunotherapy of cancer May 30, 2025
BACKGROUND: Immune checkpoint inhibitors (ICIs) have transformed the oncology treatment landscape. Despite substantial improvements for some patients, the majority do not benefit from ICIs, indicating a need for predictive biomarkers to better inform...
Humans Female Aged Algorithms Cohort Studies Immune Checkpoint Inhibitors Middle Aged Biomarkers, Tumor Neoplasms Male Treatment Outcome
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Unraveling senescence in cancer: mechanistic complexities and therapeutic opportunities.

Molecular biology reports May 30, 2025
Senescence is a pivotal cellular process, which also plays a major role in development, immune regulation, tissue repair, and aging, triggered by stressors such as telomere shortening, oncogene activation, and DNA damage. Characterized by distinct mo...
Senescence-Associated Secretory Phenotype Carcinogenesis Cellular Senescence Animals Neoplasms Humans Tumor Microenvironment
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Current status, hotspots, and trends in cancer prevention, screening, diagnosis, treatment, and rehabilitation: A bibliometric analysis.

Oncology research May 29, 2025
OBJECTIVES: Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening, targeted therapies, and immunotherapy, contributing to reduced mortality rates in cancer patients. Despit...
Early Detection of Cancer Neoplasms Bibliometrics Humans
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