AIMC Topic: Organoids

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Deep-Orga: An improved deep learning-based lightweight model for intestinal organoid detection.

Computers in biology and medicine Dec 19, 2023
PROBLEM: Organoids are 3D cultures that are commonly used for biological and medical research in vitro due to their functional and structural similarity to source organs. The development of organoids can be assessed by morphological tests. However, m...
Humans Deep Learning Labor, Obstetric Organoids Pregnancy Female Biomedical Research
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Development of a deep learning based image processing tool for enhanced organoid analysis.

Scientific reports Nov 13, 2023
Contrary to 2D cells, 3D organoid structures are composed of diverse cell types and exhibit morphologies of various sizes. Although researchers frequently monitor morphological changes, analyzing every structure with the naked eye is difficult. Given...
Recognition, Psychology Organoids Deep Learning Image Processing, Computer-Assisted Research Personnel Humans
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Deep Learning Model for Predicting Airway Organoid Differentiation.

Tissue engineering and regenerative medicine Aug 18, 2023
BACKGROUND: Organoids are self-organized three-dimensional culture systems and have the advantages of both in vitro and in vivo experiments. However, each organoid has a different degree of self-organization, and methods such as immunofluorescence st...
Humans Biomarkers Deep Learning Organoids
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OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics.

PLoS computational biology Nov 9, 2022
Organoids have immense potential as ex vivo disease models for drug discovery and personalized drug screening. Dynamic changes in individual organoid morphology, number, and size can indicate important drug responses. However, these metrics are diffi...
Organoids Drug Discovery Deep Learning High-Throughput Nucleotide Sequencing Colon
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D-CryptO: deep learning-based analysis of colon organoid morphology from brightfield images.

Lab on a chip Oct 25, 2022
Stem cell-derived organoids are a promising tool to model native human tissues as they resemble human organs functionally and structurally compared to traditional monolayer cell-based assays. For instance, colon organoids can spontaneously develop cr...
Deep Learning Intestines Organoids Humans Colon Colforsin
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Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington's disease models.

Cell reports methods Sep 19, 2022
Organoids are carrying the promise of modeling complex disease phenotypes and serving as a powerful basis for unbiased drug screens, potentially offering a more efficient drug-discovery route. However, unsolved technical bottlenecks of reproducibilit...
Drug Evaluation, Preclinical High-Throughput Screening Assays Huntington Disease Reproducibility of Results Deep Learning Organoids Humans
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Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society Aug 10, 2021
Quantitative phase imaging (QPI) is an emerging label-free technique that produces images containing morphological and dynamical information without contrast agents. Unfortunately, the phase is wrapped in most imaging system. Phase unwrapping is the ...
Mice Animals Algorithms Microscopy Deep Learning Holography Intestine, Small Image Processing, Computer-Assisted Cells, Cultured Tissue Culture Techniques Organoids
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Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease.

Nature communications Jul 12, 2021
Modeling human diseases as networks simplify complex multi-cellular processes, helps understand patterns in noisy data that humans cannot find, and thereby improves precision in prediction. Using Inflammatory Bowel Disease (IBD) as an example, here w...
Molecular Targeted Therapy Likelihood Functions Dextran Sulfate Colitis Organoids AMP-Activated Protein Kinases Multigene Family Gene Expression Regulation Intestinal Mucosa Mice, Knockout Animals Cohort Studies Mice Treatment Outcome Disease Models, Animal Mice, Inbred C57BL Machine Learning Inflammatory Bowel Diseases Reproducibility of Results Humans Artificial Intelligence
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A deep learning model for detection and tracking in high-throughput images of organoid.

Computers in biology and medicine May 25, 2021
Organoid, an in vitro 3D culture, has extremely high similarity with its source organ or tissue, which creates a model in vitro that simulates the in vivo environment. Organoids have been extensively studied in cell biology, precision medicine, drug ...
Neural Networks, Computer Precision Medicine Deep Learning Organoids
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Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning.

PLoS computational biology Feb 22, 2021
Phenotypic profiling of large three-dimensional microscopy data sets has not been widely adopted due to the challenges posed by cell segmentation and feature selection. The computational demands of automated processing further limit analysis of hard-...
Programming Languages Mammary Glands, Human Organoids Software Autophagy Algorithms Microscopy, Fluorescence Phenotype Neurons Humans Mice, Inbred C57BL Machine Learning Cell Line Image Processing, Computer-Assisted Mice Apoptosis Brain Animals Imaging, Three-Dimensional
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