AIMC Topic: Organoids

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OctoShaker: A versatile robotic biomechanical agitator for cellular and organoid research.

The Review of scientific instruments
Mechanical forces have increasingly been recognized as a key regulator in the fate of cellular development and functionality. Different mechanical transduction methods, such as substrate stiffness and magnetic bead vibration, have been experimented w...

A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids.

Cancer biology & medicine
OBJECTIVE: Organoids are a powerful tool with broad application prospects in biomedicine. Notably, they provide alternatives to animal models for testing potential drugs before clinical trials. However, the number of passages for which organoids main...

Human Retinal Organoids in Therapeutic Discovery: A Review of Applications.

Handbook of experimental pharmacology
Human embryonic stem cells (hESCs)- and induced pluripotent stem cells (hiPSCs)-derived retinal organoids (ROs) are three-dimensional laminar structures that recapitulate the developmental trajectory of the human retina. The ROs provide a fascinating...

How Brain Organoids Are Revolutionizing Neuroscience.

IEEE pulse
Measuring just a millimeter or two in diameter, brain organoids are a far cry from a fully functioning human brain. But these miniature tissues, typically derived from stem cells, are increasingly able to mimic the structure and function of our most ...

An enhanced loss function simplifies the deep learning model for characterizing the 3D organoid models.

Bioinformatics (Oxford, England)
MOTIVATION: Organization of the organoid models, imaged in 3D with a confocal microscope, is an essential morphometric index to assess responses to stress or therapeutic targets. In fact, differentiating malignant and normal cells is often difficult ...

Deep-LUMEN assay - human lung epithelial spheroid classification from brightfield images using deep learning.

Lab on a chip
Three-dimensional (3D) tissue models such as epithelial spheroids or organoids have become popular for pre-clinical drug studies. In contrast to 2D monolayer culture, the characterization of 3D tissue models from non-invasive brightfield images is a ...