AIMC Topic: Organoids
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Advancements in Organoid-Based Drug Discovery: Revolutionizing Precision Medicine and Pharmacology.
Drug development research
Jun 1, 2025
Organoids, 3D cellular models derived from stem cells, have revolutionized drug testing by providing human-relevant systems for modeling diseases and testing drug efficacy. Unlike traditional 2D cell cultures or animal models, organoids closely resem...
Model Systems of Chronic Kidney Disease: A Detailed Overview and Recent Advances.
Journal of biochemical and molecular toxicology
Jun 1, 2025
Experimental model systems, especially animal models, are indispensable tools to study human diseases and to develop new therapeutics. Chronic kidney disease (CKD) is a major global health problem having significantly higher rate of morbidity and mor...
A comprehensive update on the application of high-throughput fluorescence imaging for novel drug discovery.
Expert opinion on drug discovery
Jun 1, 2025
INTRODUCTION: High-throughput fluorescence imaging (HTFI) is revolutionizing drug discovery by enabling rapid and precise detection of biological targets and cellular processes. Recent advances in fluorescence imaging technologies now provide unprece...
OrgXenomics: an integrated proteomic knowledge base for patient-derived organoid and xenograft.
Nucleic acids research
Jan 6, 2025
Patient-derived models (PDMs, particularly organoids and xenografts) are irreplaceable tools for precision medicine, from target development to lead identification, then to preclinical evaluation, and finally to clinical decision-making. So far, PDM-...
Design optimization of geometrically confined cardiac organoids enabled by machine learning techniques.
Cell reports methods
Jun 17, 2024
Stem cell organoids are powerful models for studying organ development, disease modeling, drug screening, and regenerative medicine applications. The convergence of organoid technology, tissue engineering, and artificial intelligence (AI) could poten...
OctoShaker: A versatile robotic biomechanical agitator for cellular and organoid research.
The Review of scientific instruments
Dec 1, 2023
Mechanical forces have increasingly been recognized as a key regulator in the fate of cellular development and functionality. Different mechanical transduction methods, such as substrate stiffness and magnetic bead vibration, have been experimented w...
A quick and reliable image-based AI algorithm for evaluating cellular senescence of gastric organoids.
Cancer biology & medicine
Jun 30, 2023
OBJECTIVE: Organoids are a powerful tool with broad application prospects in biomedicine. Notably, they provide alternatives to animal models for testing potential drugs before clinical trials. However, the number of passages for which organoids main...
Human Retinal Organoids in Therapeutic Discovery: A Review of Applications.
Handbook of experimental pharmacology
Jan 1, 2023
Human embryonic stem cells (hESCs)- and induced pluripotent stem cells (hiPSCs)-derived retinal organoids (ROs) are three-dimensional laminar structures that recapitulate the developmental trajectory of the human retina. The ROs provide a fascinating...
How Brain Organoids Are Revolutionizing Neuroscience.
IEEE pulse
Jan 1, 2023
Measuring just a millimeter or two in diameter, brain organoids are a far cry from a fully functioning human brain. But these miniature tissues, typically derived from stem cells, are increasingly able to mimic the structure and function of our most ...
An enhanced loss function simplifies the deep learning model for characterizing the 3D organoid models.
Bioinformatics (Oxford, England)
Sep 29, 2021
MOTIVATION: Organization of the organoid models, imaged in 3D with a confocal microscope, is an essential morphometric index to assess responses to stress or therapeutic targets. In fact, differentiating malignant and normal cells is often difficult ...
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