AIMC Topic: Thalidomide

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Integrated experimental, computational and machine learning approaches for the development of Apremilast-Aceclofenac coamorphous systems.

International journal of pharmaceutics
Understanding the molecular mechanisms of drug coamorphization remains a key challenge in solid-state pharmaceutics. This study presents a molecular level strategy for designing drug-drug coamorphous systems (CAMs) of apremilast (APR) and aceclofenac...

The effect of thalidomide on the invasive ability of gastric cancer cells by regulating miR-524-5p/FSTL1.

Cellular and molecular biology (Noisy-le-Grand, France)
This study aimed to investigate the effect of thalidomide (Thal) regulating microRNA (miR)-524-5p/follistatin-like protein 1 (FSTL1) on the invasion ability of gastric cancer cells. For this purpose, real-time fluorescent quantitative PCR (RT-qPCR) w...

Building the drug-GO function network to screen significant candidate drugs for myasthenia gravis.

PloS one
Myasthenia gravis (MG) is an autoimmune disease. In recent years, considerable evidence has indicated that Gene Ontology (GO) functions, especially GO-biological processes, have important effects on the mechanisms and treatments of different diseases...