AIMC Topic: Polymorphism, Genetic

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SOMmelier-Intuitive Visualization of the Topology of Grapevine Genome Landscapes Using Artificial Neural Networks.

Genes Jul 17, 2020
BACKGROUND: Whole-genome studies of vine cultivars have brought novel knowledge about the diversity, geographical relatedness, historical origin and dissemination, phenotype associations and genetic markers.
Databases, Genetic Vitis Polymorphism, Genetic Genome, Plant Quantitative Trait, Heritable Neural Networks, Computer Genome-Wide Association Study
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Comparison of the predictive outcomes for anti-tuberculosis drug-induced hepatotoxicity by different machine learning techniques.

Computer methods and programs in biomedicine Dec 27, 2019
BACKGROUND: The study compared the predictive outcomes of artificial neural network, support vector machine and random forest on the occurrence of anti-tuberculosis drug-induced hepatotoxicity.
Humans Tuberculosis Gene Frequency Polymorphism, Genetic Chemical and Drug Induced Liver Injury Risk Factors Male Neural Networks, Computer Genotype Aged Middle Aged Support Vector Machine Machine Learning Aged, 80 and over Drug Discovery Liver Female Adult ROC Curve Taiwan Reproducibility of Results Sensitivity and Specificity Genomics Antitubercular Agents
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PharmVar GeneFocus: CYP2D6.

Clinical pharmacology and therapeutics Dec 9, 2019
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocu...
Humans Pharmacogenetics Databases, Genetic Pharmaceutical Preparations Knowledge Bases Genetic Variation Polymorphism, Genetic Cytochrome P-450 CYP2D6
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Factors involved in phenoconversion of CYP3A using 4β-hydroxycholesterol in stable kidney transplant recipients.

Pharmacological reports : PR Dec 15, 2018
BACKGROUND: Phenoconversion is a phenomenon whereby some genotypic extensive metabolizers transiently exhibit drug metabolizing enzyme activity at similar level as that of poor metabolizers. Renal failure is known to decrease CYP3A activity in humans...
Indican Tumor Necrosis Factor-alpha Kidney Transplantation Interleukin-6 Female Aged Alleles Humans Young Adult Parathyroid Hormone Polymorphism, Genetic Adult Cytochrome P-450 CYP3A Male Hydroxycholesterols Middle Aged Genotype
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Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Oct 25, 2018
OBJECTIVES: To evaluate the association of mannose-binding lectin (MBL) deficiency with susceptibility and clinical features of group B Streptococcus (GBS) causing meningitis in Chinese infants.
Meningitis, Bacterial Case-Control Studies Young Adult Metabolism, Inborn Errors China Alleles Adult Polymorphism, Genetic Humans Genotype Streptococcal Infections Male Genetic Association Studies Female Streptococcus agalactiae Middle Aged Infant, Newborn Disease Susceptibility Infant Risk Factors Mannose-Binding Lectin
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A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes.

European journal of pain (London, England) Jul 13, 2018
BACKGROUND: Human genetic research has implicated functional variants of more than one hundred genes in the modulation of persisting pain. Artificial intelligence and machine-learning techniques may combine this knowledge with results of genetic rese...
Cluster Analysis Pain Polymorphism, Genetic Neuroimmunomodulation Humans Machine Learning Phenotype
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Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris.

Clinical and experimental dermatology Dec 28, 2017
The aim of this study was to detect the association of the cytochrome P450 (CYP) 17 T-34C and CYP19 T
Genotype Iran Polymorphism, Genetic Acne Vulgaris Aromatase Steroid 17-alpha-Hydroxylase Adult Male Case-Control Studies Adolescent Genetic Predisposition to Disease Humans Female Young Adult
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Evaluation of CNTNAP2 gene rs2107856 polymorphism in Turkish population with pseudoexfoliation syndrome.

International ophthalmology Dec 19, 2017
PURPOSE: To investigate rs2107856 single-nucleotide polymorphism (SNP) of CNTNAP2 gene in Turkish population with pseudoexfoliation and to correlate clinical characteristics with the genotypic profile.
Humans Prospective Studies Female Nerve Tissue Proteins Visual Acuity Tomography, Optical Coherence DNA Turkey Retinal Ganglion Cells Polymerase Chain Reaction Male Aged Polymorphism, Genetic Middle Aged Exfoliation Syndrome Aged, 80 and over Incidence Cross-Sectional Studies Genotype Intraocular Pressure Membrane Proteins
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Bayesian Machine Learning Techniques for revealing complex interactions among genetic and clinical factors in association with extra-intestinal Manifestations in IBD patients.

AMIA ... Annual Symposium proceedings. AMIA Symposium Feb 10, 2017
The objective of the study is to assess the predictive performance of three different techniques as classifiers for extra-intestinal manifestations in 152 patients with Crohn's disease. Naïve Bayes, Bayesian Additive Regression Trees and Bayesian Net...
Data Mining Polymorphism, Genetic Male Genetic Predisposition to Disease Models, Statistical Machine Learning Bayes Theorem Humans Crohn Disease Algorithms Female Risk Factors
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Development of neuro-fuzzy model to explore gene-nutrient interactions modulating warfarin dose requirement.

Pharmacogenomics Jul 27, 2016
AIM: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement.
Models, Neurological Anticoagulants Warfarin Asian People Genetic Variation Adolescent Child Genotype Fuzzy Logic Vitamin K Polymorphism, Genetic Humans Female Aged Young Adult Adult Male Middle Aged
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