AIMC Topic: Precision Medicine
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Innate immune cell barrier-related genes inform precision prognosis in pancreatic cancer.
Frontiers in immunology
May 23, 2025
INTRODUCTION: Pancreatic cancer (PC) remains a lethal malignancy with limited treatment options. The role of innate immune cell barrier-related genes in PC prognosis is poorly defined. This study aimed to identify prognostic biomarkers, develop a pre...
Learning double balancing representation for heterogeneous dose-response curve estimation.
Neural networks : the official journal of the International Neural Network Society
May 22, 2025
Estimating the individuals' potential response to varying treatment doses is crucial for decision-making in areas such as precision medicine and management science. Most recent studies predict counterfactual outcomes by learning a covariate represent...
Induced Pluripotent Stem Cells in Cardiomyopathy: Advancing Disease Modeling, Therapeutic Development, and Regenerative Therapy.
International journal of molecular sciences
May 22, 2025
Cardiomyopathies are a heterogeneous group of heart muscle diseases that can lead to heart failure, arrhythmias, and sudden cardiac death. Traditional animal models and in vitro systems have limitations in replicating the complex pathology of human c...
Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy.
Science advances
May 21, 2025
Neoantigens have emerged as ideal targets for personalized cancer immunotherapy. We depict the pan-cancer peptide atlas by comprehensively collecting immunopeptidomics from 531 samples across 14 cancer and 29 normal tissues, and identify 389,165 cano...
A data-driven scoring framework for personalized employee health check-ups: Integrating historical laboratory trends and evidence-based prevalence.
International journal of medical informatics
May 18, 2025
INTRODUCTION: Rising healthcare costs and growing demand for personalized preventive care have highlighted the need for data-driven approaches to optimize health check-ups, particularly in corporate settings. This study presents a scoring-based platf...
Gene expression and agent-based modeling improve precision prognosis in breast cancer.
Scientific reports
May 16, 2025
Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will ...
A novel transfer learning framework for non-uniform conductivity estimation with limited data in personalized brain stimulation.
Physics in medicine and biology
May 6, 2025
. Personalized transcranial magnetic stimulation (TMS) requires individualized head models that incorporate non-uniform conductivity to enable target-specific stimulation. Accurately estimating non-uniform conductivity in individualized head models r...
Unraveling MASLD: The Role of Gut Microbiota, Dietary Modulation, and AI-Driven Lifestyle Interventions.
Nutrients
May 4, 2025
Gut microbiota has a crucial role in the pathophysiology of metabolic-associated steatotic liver disease (MASLD), influencing various metabolic mechanisms and contributing to the development of the disease. Dietary interventions targeting gut microbi...
Recent advances in omics and the integration of multi-omics in osteoarthritis research.
Arthritis research & therapy
May 3, 2025
Osteoarthritis (OA) is a complex disorder driven by the combination of environmental and genetic factors. Given its high global prevalence and heterogeneity, developing effective and personalized treatment methods is crucial. This requires identifyin...
Harnessing an Artificial Intelligence-Based Large Language Model With Personal Health Record Capability for Personalized Information Support in Postsurgery Myocardial Infarction: Descriptive Qualitative Study.
Journal of medical Internet research
Apr 30, 2025
BACKGROUND: Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Although postsurgical cardiac interventions have improved survival rates, effective management during recovery remains challenging. Traditional infor...
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