AIMC Topic: Precision Medicine

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AI-driven multi-omics integration in precision oncology: bridging the data deluge to clinical decisions.

Clinical and experimental medicine
Cancer's staggering molecular heterogeneity demands innovative approaches beyond traditional single-omics methods. The integration of multi-omics data, spanning genomics, transcriptomics, proteomics, metabolomics and radiomics, can improve diagnostic...

Data-driven cluster analysis identifies three clinical phenotypes in hemodialysis patients.

Renal failure
Clinical heterogeneity among hemodialysis patients necessitates precision medicine approaches transcending conventional single-parameter management. Through machine learning analysis of 1,207 maintenance hemodialysis patients, we developed a novel tw...

Reducing Artifact Preprocessing in Heart Rate Variability-Based Personalized Psychosis Prediction Using Adaptive Long Short-Term Memory Models.

International journal of neural systems
This research looks at the use of long-short-term memory (LSTM) networks to predict psychosis, in patients within the schizophrenia spectrum, based on Heart Rate Variability (HRV) data acquired from wearable devices. Our primary objective is to test ...

Ethical challenges in biomarker research and precision medicine - a qualitative study in dermatology.

BMC medical ethics
BACKGROUND: Over 300 million individuals worldwide live with Atopic Dermatitis and Psoriasis, which are among the most common chronic inflammatory skin diseases. Multimodal biomarkers are currently being developed using large-scale data and artificia...

Data-augmented machine learning for personalized carbohydrate-protein supplement recommendation for endurance.

Scientific reports
Carbohydrate-protein supplementation often improves endurance performance. However, effectiveness varies significantly among individuals due to unique personal characteristics. This study aimed to develop a predictive machine learning framework for p...

Precision medicine exploration of postpartum rectus abdominis muscle separation: from basic research to clinical practice.

BMC surgery
Postpartum diastasis recti abdominis (PDRA), characterized by pathological separation of the rectus abdominis muscles, affects 30%-60% of women, with many cases persisting beyond 6 months postpartum and having significant impacts on musculoskeletal f...

Genetic and Genomic Testing in Cardiovascular Disease: A Policy Statement From the American Heart Association.

Circulation
The rapid advancement of genomic and precision medicine has expanded the role of genetics and genomics in the diagnosis, risk stratification, and management of cardiovascular diseases. With the decreasing cost and increasing accessibility of genetic ...

Dynamic Changes in Metabolic Syndrome Scores and New-Onset Stroke Risk in Middle-Aged and Older Adults: A Nationwide Prospective Cohort Study in China Aligned With Predictive, Preventive, and Personalized Medicine.

Journal of the American Heart Association
BACKGROUND: Despite the established link between metabolic syndrome (MetS) and stroke incidence, the effects of dynamic and cumulative MetS scores on stroke risk among middle-aged and older populations in China remain inadequately explored. Furthermo...

Advancing post-stroke blood pressure management: an individualized BP strategy for function optimization.

Annals of medicine
BACKGROUND: Stroke remains a major global public health concern and a leading cause of death, disability, and dementia. Despite being the most important and modifiable risk factor for stroke, Blood pressure (BP) management remain controversial and ch...

Conditional VAE for personalized neurofeedback in cognitive training.

PloS one
Machine learning (ML) offers great potential in healthcare, especially in the analysis of complex physiological signals like electroencephalography (EEG). EEG recordings hold valuable insights into neurological function and can aid in diagnosing vari...