AIMC Topic: Proof of Concept Study

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Leveraging Machine Learning to Identify Subgroups of Misclassified Patients in the Emergency Department: Multicenter Proof-of-Concept Study.

Journal of medical Internet research
BACKGROUND: Hospitals use triage systems to prioritize the needs of patients within available resources. Misclassification of a patient can lead to either adverse outcomes in a patient who did not receive appropriate care in the case of undertriage o...

Development of two machine learning models to predict conversion from primary HER2-0 breast cancer to HER2-low metastases: a proof-of-concept study.

ESMO open
BACKGROUND: HER2-low expression has gained clinical relevance in breast cancer (BC) due to the availability of anti-HER2 antibody-drug conjugates for patients with HER2-low metastatic BC. The well-reported instability of HER2-low status during diseas...

Deep learning and radiomics-based vascular calcification characterization in dental cone beam computed tomography as a predictive tool for cardiovascular disease: a proof-of-concept study.

Oral surgery, oral medicine, oral pathology and oral radiology
OBJECTIVES: This study evaluated an automated deep learning method for detecting calcifications in the extracranial and intracranial carotid arteries and vertebral arteries in cone beam computed tomography (CBCT) scans. Additionally, a model utilizin...

Photonic platform coupled with machine learning algorithms to detect pyrolysis products of crack cocaine in saliva: A proof-of-concept animal study.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
The non-invasive detection of crack/cocaine and other bioactive compounds from its pyrolysis in saliva can provide an alternative for drug analysis in forensic toxicology. Therefore, a highly sensitive, fast, reagent-free, and sustainable approach wi...

Concordance-based Predictive Uncertainty (CPU)-Index: Proof-of-concept with application towards improved specificity of lung cancers on low dose screening CT.

Artificial intelligence in medicine
In this paper, we introduce a novel concordance-based predictive uncertainty (CPU)-Index, which integrates insights from subgroup analysis and personalized AI time-to-event models. Through its application in refining lung cancer screening (LCS) predi...

Development and validation of an AI-driven tool to evaluate chewing function: a proof of concept.

Journal of dentistry
BACKGROUND: Masticatory function is an important determinant of oral health and a contributing factor in the maintenance of general health. Currently, objective assessment of chewing function is a clinical challenge. Previously, several methods have ...

Automatic identification of clinically important species by artificial intelligence-based image recognition: proof-of-concept study.

Emerging microbes & infections
While morphological examination is the most widely used for identification in clinical laboratories, PCR-sequencing and MALDI-TOF MS are emerging technologies in more financially-competent laboratories. However, mycological expertise, molecular biol...

Detection of basal cell carcinoma by machine learning-assisted ex vivo confocal laser scanning microscopy.

International journal of dermatology
BACKGROUND: Ex vivo confocal laser scanning microscopy (EVCM) is an emerging imaging modality that enables near real-time histology of whole tissue samples. However, the adoption of EVCM into clinical routine is partly limited because the recognition...

Integrating machine learning-predicted circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in metastatic breast cancer: A proof of principle study on endocrine resistance profiling.

Cancer letters
The study explored endocrine resistance by leveraging machine learning to establish the prognostic stratification of predicted Circulating tumor cells (CTCs), assessing its integration with circulating tumor DNA (ctDNA) features and contextually eval...

Multi-Institutional Evaluation and Training of Breast Density Classification AI Algorithm Using ACR Connect and AI-LAB.

Journal of the American College of Radiology : JACR
OBJECTIVE: To demonstrate and test the capabilities of the ACR Connect and AI-LAB software platform by implementing multi-institutional artificial intelligence (AI) training and validation for breast density classification.