AIMC Topic: RNA, Messenger
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Prediction of mRNA subcellular localization using deep recurrent neural networks.
Bioinformatics (Oxford, England)
Jul 15, 2019
MOTIVATION: Messenger RNA subcellular localization mechanisms play a crucial role in post-transcriptional gene regulation. This trafficking is mediated by trans-acting RNA-binding proteins interacting with cis-regulatory elements called zipcodes. Whi...
DeepDSSR: Deep Learning Structure for Human Donor Splice Sites Recognition.
Studies in health technology and informatics
Jul 4, 2019
Human genes often, through alternative splicing of pre-messenger RNAs, produce multiple mRNAs and protein isoforms that may have similar or completely different functions. Identification of splice sites is, therefore, crucial to understand the gene s...
DeepMirTar: a deep-learning approach for predicting human miRNA targets.
Bioinformatics (Oxford, England)
Nov 15, 2018
MOTIVATION: MicroRNAs (miRNAs) are small non-coding RNAs that function in RNA silencing and post-transcriptional regulation of gene expression by targeting messenger RNAs (mRNAs). Because the underlying mechanisms associated with miRNA binding to mRN...
A deep recurrent neural network discovers complex biological rules to decipher RNA protein-coding potential.
Nucleic acids research
Sep 19, 2018
The current deluge of newly identified RNA transcripts presents a singular opportunity for improved assessment of coding potential, a cornerstone of genome annotation, and for machine-driven discovery of biological knowledge. While traditional, featu...
Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis.
Current molecular medicine
Jan 1, 2018
PURPOSE: Protein sumoylation is a well established regulatory mechanism that regulates chromatin structure and dynamics, cell proliferation and differentiation, stress response and cell apoptosis. In the vertebrate eye, we and others have shown that ...
[Role of high mobility group protein B1 in IL-1α-induced endothelial cell senescence].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Dec 28, 2017
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
Methods: HUVECs were randomly divided into a control group, a IL-1α group...
[Effect of Acupuncture at Points in Heel Vessel for Circadian Genes of 1 and 2 mRNAs in the Suprachiasmatic Nucleus in Insomnia Rats].
Zhen ci yan jiu = Acupuncture research
Dec 25, 2017
OBJECTIVE: To investigate the influence and mechanism of acupuncture at the points in Heel Vessel for the circadian clock genes of Period () 1 and 2 mRNAs in the suprachiasmatic nucleus (SCN) in insomnia rats.
Evaluation of luteinizing hormone regulation of maturation and apoptosis, expression of LHR and FSHR in cumulus-oocyte complexes in Lanzhou fat-tailed sheep.
Polish journal of veterinary sciences
Dec 1, 2017
The present study aimed to assess LH effects on in vitro maturation (IVM) and apoptosis and also to explore the gene expressions of LHR and FSHR in cumulus-oocyte complexes (COCs) of the sheep. COCs were in vitro matured 24h in the IVM medium supplem...
Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2017
In recent years, the role of miRNAs in post-transcriptional gene regulation has provided new insights into the understanding of several types of cancers and neurological disorders. Although miRNA research has gathered great momentum since its discove...
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