AIMC Topic: RNA, Viral
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Stem loop binding protein promotes SARS-CoV-2 replication via -1 programmed ribosomal frameshifting.
Signal transduction and targeted therapy
Jun 13, 2025
The -1 programmed ribosomal frameshifting (-1 PRF) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for keeping the balance between pp1a and pp1ab polyproteins. To date, the host factors influencing this process remain poorl...
Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay.
Molecular medicine (Cambridge, Mass.)
May 30, 2025
BACKGROUND: Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human papillomaviruses (hrHPV), the causative agents of cervix cancer. Although hrHPV infection is a pre-re...
Surveillance of SARS-CoV-2 RNA in wastewater treatment plants in Türkiye, Istanbul: a long-term study and statistical analysis.
Environmental monitoring and assessment
May 12, 2025
Wastewater-based epidemiology (WBE) is a powerful method that allows community surveillance to identify diseases/pandemic dynamics in a city, especially in metropolitan areas with high overpopulation. This study investigated the detection and quantif...
RNA-protein interaction prediction using network-guided deep learning.
Communications biology
Feb 16, 2025
Accurate computational determination of RNA-protein interactions remains challenging, particularly when encountering unknown RNAs and proteins. The limited number of RNAs and their flexibility constrained the effectiveness of the deep-learning models...
The efficiency of artificial intelligence for management and clinical decision-making in the identification of patients with hidden HCV infection (Intelligen-C strategy).
Gastroenterologia y hepatologia
Jan 18, 2025
INTRODUCTION: Artificial intelligence (AI) allows the optimization of diagnostic processes for hepatitis C virus (HCV) patients. Our objective was to evaluate the clinical, economic, and management benefits of an AI-based clinical decision support sy...
Enhanced Sampling Simulations of RNA-Peptide Binding Using Deep Learning Collective Variables.
Journal of chemical information and modeling
Jan 7, 2025
Enhanced sampling (ES) simulations of biomolecular recognition, such as binding small molecules to proteins and nucleic acid targets, protein-protein association, and protein-nucleic acid interactions, have gained significant attention in the simulat...
Enhancing SARS-CoV-2 Lineage Surveillance through the Integration of a Simple and Direct qPCR-Based Protocol Adaptation with Established Machine Learning Algorithms.
Analytical chemistry
Nov 4, 2024
Emerging and evolving Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) lineages, adapted to changing epidemiological conditions, present unprecedented challenges to global public health systems. Here, we introduce an adapted analytical ap...
A potential new way to facilitate HCV elimination: The prediction of viremia in anti-HCV seropositive patients using machine learning algorithms.
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
May 4, 2024
BACKGROUND AND STUDY AIMS: The present study was undertaken to design a new machine learning (ML) model that can predict the presence of viremia in hepatitis C virus (HCV) antibody (anti-HCV) seropositive cases.
Comparison of hepatitis B and SARS-CoV2 vaccination rates in people who attended Drugs and Addiction Centres.
Frontiers in public health
Jan 16, 2024
BACKGROUND AND AIMS: Persons with substance use disorder are at increased risk for hepatitis B virus (HBV) infection. Although most of them are attached to social health centers, the vaccination rate in this group is low. In this context, we designed...
Early-stage neutralizing antibody level associated with the re-positive risk of Omicron SARS-CoV-2 RNA in patients recovered from COVID-19.
Diagnostic microbiology and infectious disease
Dec 17, 2023
Post-discharge re-positivity of Omicron SARS-CoV-2 is challenging for the sufficient control of this pandemic. However, there are few studies about the risk of re-positivity. We aimed to explore the association of neutralizing antibodies (nAbs, AU/mL...
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