Since the promulgation of the July 21, 2009 law on hospital reform and patients, health and territories, known as the HPST law, therapeutic patient education (TPE) and telemedicine have become key pillars in the modernization of the healthcare system...
INTRODUCTION: Machine learning models have been employed to predict COVID-19 infections and mortality, but many models were built on training and testing sets from different periods. The purpose of this study is to investigate the impact of temporali...
Journal of neuroengineering and rehabilitation
40269913
BACKGROUND: Telerehabilitation allows patients to engage in therapy away from healthcare facilities, often in the comfort of their homes. Studies have suggested that it can effectively improve motor and cognitive function. However, its applicability ...
Microfluidic biosensors offer a promising solution for real-time analysis of coronaviruses with minimal sample volumes. This study optimizes a biochip for the rapid detection of SARS-CoV-2 using the Taguchi orthogonal table L(3), which comprises nine...
Stress and health : journal of the International Society for the Investigation of Stress
40261245
Online self-guided interventions appear efficacious for alleviating some mental health concerns. However, among persons who are offered online interventions, only a fraction access them (i.e., achieve uptake). Machine learning methods may be useful t...
The design of proteins capable effectively binding to specific protein targets is crucial for developing therapies, diagnostics, and vaccine candidates for viral infections. Here, we introduce a complementarity-determining region (CDR) grafting appro...
BACKGROUND: The COVID-19 pandemic intensified the challenges associated with mental health and substance use (SU), with societal and economic upheavals leading to heightened stress and increased reliance on drugs as a coping mechanism. Centers for Di...
International journal of molecular sciences
40244295
This study explores the role of intrinsically disordered regions (IDRs) in the SARS-CoV-2 proteome and their potential as targets for small-molecule drug discovery. Experimentally validated intrinsic disordered regions from the literature were utiliz...
BACKGROUND: Methods that enable early outbreak detection represent powerful tools in epidemiological surveillance, allowing adequate planning and timely response to disease surges. Syndromic surveillance data collected from primary healthcare encount...
Bioactivity optimization is a crucial and technical task in the early stages of drug discovery, traditionally carried out through iterative substituent optimization, a process that is often both time-consuming and expensive. To address this challenge...