AIMC Topic: Sesquiterpenes
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Insight into endophytic microbiota-driven geographical and bioactive signatures toward a novel quality assessment model for Codonopsis Radix.
Plant physiology and biochemistry : PPB
Apr 4, 2025
Codonopsis Radix, a medicinal and dietary herb in traditional Chinese medicine, largely owes its pharmacological efficacy to both intrinsic phytochemistry and symbiotic interactions with plant-associated microbes. Here, we deciphered the geo-environm...
Potential of hyperspectral imaging for nondestructive determination of α-farnesene and conjugated trienol content in 'Yali' pear.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jun 19, 2024
The sesquiterpene α-farnesene and its corresponding oxidation products, namely conjugated trienols (CTols) is well known to be correlated with the development of superficial scald, a typical physiological disorder after a long term of cold storage in...
Integrating structure-based machine learning and co-evolution to investigate specificity in plant sesquiterpene synthases.
PLoS computational biology
Mar 22, 2021
Sesquiterpene synthases (STSs) catalyze the formation of a large class of plant volatiles called sesquiterpenes. While thousands of putative STS sequences from diverse plant species are available, only a small number of them have been functionally ch...
Computational planning of the synthesis of complex natural products.
Nature
Oct 13, 2020
Training algorithms to computationally plan multistep organic syntheses has been a challenge for more than 50 years. However, the field has progressed greatly since the development of early programs such as LHASA, for which reaction choices at each s...
Machine learning for target discovery in drug development.
Current opinion in chemical biology
Nov 14, 2019
The discovery of macromolecular targets for bioactive agents is currently a bottleneck for the informed design of chemical probes and drug leads. Typically, activity profiling against genetically manipulated cell lines or chemical proteomics is pursu...
The antifibrotic effect of isolate tagitinin C from tithonia diversifolia (Hemsley) A. Gray on keloid fibroblast cell.
The Pan African medical journal
Aug 8, 2018
INTRODUCTION: Keloids characterized by fibroblast hyperproliferation and depositions of collagen which similar to cancer cells. Tagitinin C is a class of sesquiterpene lactones (SLS) was isolated from the leaves of the moon flower (Hemsley) A. Gray....
Structure-activity relationship studies of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters against influenza viruses.
Bioorganic & medicinal chemistry letters
Jun 6, 2016
A series of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters were synthesized via the condensation of methyl rupestonate with various aldehydes in the presence of LDA. This mixed aldol reaction was highly stereoselective and all the new compounds wer...
Sesquiterpene lactone containing extracts from two cultivars of forage chicory (Cichorium intybus) show distinctive chemical profiles and in vitro activity against Ostertagia ostertagi.
International journal for parasitology. Drugs and drug resistance
Oct 22, 2015
The study investigated direct anthelmintic effects of sesquiterpene lactones (SL)-containing extracts from forage chicory against free-living and parasitic stages of Ostertagia ostertagi. Freeze-dried leaves from chicory cultivars 'Spadona' and 'Puna...
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from .
Pharmaceutical biology
Dec 1, 2021
CONTEXT: Traditionally, Hook. f. (Asteraceae) has been reported to be effective in cancer treatment which motivated the authors to explore the plant for novel anticancer compounds.
Immunomodulation of Zerumbone via Decreasing the Production of Reactive Oxygen Species from Immune Cells.
Pakistan journal of biological sciences : PJBS
Jan 1, 2018
BACKGROUND AND OBJECTIVE: Zerumbone has been reported to exert anti-inflammatory, anti-ulcer and anti-hyperglycemic effects but the specific mechanism through which zerumbone exerts its anti-inflammatory action through inhibiting reactive oxygen spec...
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