AIMC Topic: Severity of Illness Index
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Using machine learning to identify Parkinson's disease severity subtypes with multimodal data.
Journal of neuroengineering and rehabilitation
Jun 2, 2025
BACKGROUND: Classifying and predicting Parkinson's disease (PD) is challenging because of its diverse subtypes based on severity levels. Currently, identifying objective biomarkers associated with disease severity that can distinguish PD subtypes in ...
Estimating motor symptom presence and severity in Parkinson's disease from wrist accelerometer time series using ROCKET and InceptionTime.
Scientific reports
May 31, 2025
Parkinson's disease (PD) is a neurodegenerative condition characterized by frequently changing motor symptoms, necessitating continuous symptom monitoring for more targeted treatment. Classical time series classification and deep learning techniques ...
Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety.
BMC psychiatry
May 30, 2025
BACKGROUND: Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Identifying p...
A data-centric and interpretable EEG framework for depression severity grading using SHAP-based insights.
Journal of neuroengineering and rehabilitation
May 25, 2025
BACKGROUND: Major Depressive Disorder is a leading cause of disability worldwide. An accurate assessment of depression severity is critical for diagnosis, treatment planning, and monitoring, yet current clinical tools are largely subjective, relying ...
Development of a risk prediction model for secondary infection in severe/critical COVID-19 patients.
BMC infectious diseases
May 21, 2025
OBJECTIVE: This study aimed to develop a predictive model for secondary infections in patients with severe or critical COVID-19 by analyzing clinical characteristics and laboratory indicators.
Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.
Metabolomics : Official journal of the Metabolomic Society
May 21, 2025
INTRODUCTION: There are significant challenges remain in accurately categorizing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients.
Investigation of serum neuroserpin levels in pregnant women diagnosed with pre-eclampsia: a prospective case-control study.
BMC pregnancy and childbirth
May 10, 2025
OBJECTIVE: Neuroserpin, a serine protease inhibitor, is recognized for its anti-inflammatory and neuroprotective properties. Given the central role of inflammation and neurological involvement in the pathophysiology of preeclampsia, this study aimed ...
Deep learning-based evaluation of the severity of mitral regurgitation in canine myxomatous mitral valve disease patients using digital stethoscope recordings.
BMC veterinary research
May 8, 2025
BACKGROUND: Myxomatous mitral valve disease (MMVD) represents the most prevalent cardiac disorder in dogs, frequently resulting in mitral regurgitation (MR) and congestive heart failure. Although echocardiography is the gold standard for diagnosis, i...
Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches.
Frontiers in cellular and infection microbiology
May 2, 2025
INTRODUCTION: HIV-associated cryptococcosis is marked by unpredictable disease trajectories and persistently high mortality rates worldwide. Although improved risk stratification and tailored clinical management are urgently needed to enhance patient...
Development and validation of a novel chronic pancreatitis pathological grade based on artificial intelligence.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Apr 29, 2025
BACKGROUND: Effective chronic pancreatitis (CP) treatment requires accurate severity evaluation, but no histopathology grading system exists. This study aimed to develop and validate a novel CP pathological grade (Histopathology-derived CPpG) using q...
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