The use of machine learning (ML) in medicine is becoming increasingly fundamental to analyse complex problems by discovering associations among different types of information and to generate knowledge for medical decision support. Many regulatory and...
The Sequence Read Archive (SRA) is a large public repository that stores raw next-generation sequencing data from thousands of diverse scientific investigations. Despite its promise, reuse and re-analysis of SRA data has been challenged by the heter...
We present the Single-Cell Clustering Assessment Framework, a method for the automated identification of putative cell types from single-cell RNA sequencing (scRNA-seq) data. By iteratively applying a machine learning approach to a given set of cells...
: To describe the development and validation of an artificial intelligence-based, deep learning algorithm (DeepDR) for the detection of diabetic retinopathy (DR) in retinal fundus photographs. : Five hundred fundus images, which had detailed labellin...
Journal of chemical information and modeling
May 15, 2020
Hemolytic toxicity, as one of the key toxicity endpoints for small molecules, can cause lysis of the erythrocyte membrane and subsequent release of hemoglobin into blood plasma, leading to multiple acute and chronic adverse effects. Hence, it is nece...
In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in optic nerve (ON) tissue images from various animal models of glaucoma. We adapted deep learning to regress pixelwise axon count de...
Mass spectrometry (MS) based proteomics has become an indispensable component of modern molecular and cellular biochemistry analysis. Multiple reaction monitoring (MRM) is one of the most well-established MS techniques for molecule detection and quan...
ChIP-seq is one of the core experimental resources available to understand genome-wide epigenetic interactions and identify the functional elements associated with diseases. The analysis of ChIP-seq data is important but poses a difficult computation...
In this study, we aim to compare the performance of systems and forensic facial comparison experts in terms of likelihood ratio computation to assess the potential of the machine to support the human expert in the courtroom. In forensics, transparenc...
Neural networks : the official journal of the International Neural Network Society
May 8, 2020
Predicting salient regions in natural images requires the detection of objects that are present in a scene. To develop robust representations for this challenging task, high-level visual features at multiple spatial scales must be extracted and augme...
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