AIMC Topic: T-Lymphocytes
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Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space.
Frontiers in immunology
Apr 16, 2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different...
Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Apr 10, 2019
We previously reported a system for assessing rejection in kidney transplant biopsies using microarray-based gene expression data, the Molecular Microscope Diagnostic System (MMDx). The present study was designed to optimize the accuracy and stabilit...
Diagnosis of T-cell-mediated kidney rejection in formalin-fixed, paraffin-embedded tissues using RNA-Seq-based machine learning algorithms.
Human pathology
Oct 6, 2018
Molecular diagnosis is being increasingly used in transplant pathology to render more objective and quantitative determinations that also provide mechanistic and prognostic insights. This study performed RNA-Seq on biopsies from kidneys with stable f...
Towards the development of robot immune system: A combined approach involving innate immune cells and T-lymphocytes.
Bio Systems
Aug 10, 2018
Mobile robots in uncertain and unstructuredenvironments frequently encounter faults. Therefore, an effective fault detection and recovery mechanism is required. One can possibly investigate natural systems to seek inspiration to develop systems that ...
Using OWL reasoning to support the generation of novel gene sets for enrichment analysis.
Journal of biomedical semantics
Feb 14, 2018
BACKGROUND: The Gene Ontology (GO) consists of over 40,000 terms for biological processes, cell components and gene product activities linked into a graph structure by over 90,000 relationships. It has been used to annotate the functions and cellular...
What Is the most Important for Elite Control: Genetic Background of Patient, Genetic Background of Partner, both or neither? Description of Complete Natural History within a Couple of MSM.
EBioMedicine
Dec 7, 2017
BACKGROUND: We describe a homosexual man who strongly controlled HIV-1 for ten years despite lack of protective genetic background.
Ab-initio conformational epitope structure prediction using genetic algorithm and SVM for vaccine design.
Computer methods and programs in biomedicine
Oct 12, 2017
BACKGROUND AND OBJECTIVE: T-cell epitope structure identification is a significant challenging immunoinformatic problem within epitope-based vaccine design. Epitopes or antigenic peptides are a set of amino acids that bind with the Major Histocompati...
An immune-inspired swarm aggregation algorithm for self-healing swarm robotic systems.
Bio Systems
May 10, 2016
Swarm robotics is concerned with the decentralised coordination of multiple robots having only limited communication and interaction abilities. Although fault tolerance and robustness to individual robot failures have often been used to justify the u...
Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.
Clinical nutrition (Edinburgh, Scotland)
Dec 24, 2015
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...
NIEluter: Predicting peptides eluted from HLA class I molecules.
Journal of immunological methods
Apr 7, 2015
The immune system has evolved to make a diverse repertoire of peptides processed from self and foreign proteomes, which are displayed in antigen-binding grooves of major histocompatibility complex (MHC) proteins at cell surface for surveillance by T ...
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