AIMC Topic: Tablets
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Innovative spectrophotometric methods for simultaneous estimation of the novel two-drug combination: Sacubitril/Valsartan through two manipulation approaches and a comparative statistical study.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Dec 17, 2017
Different innovative spectrophotometric methods were introduced for the first time for simultaneous quantification of sacubitril/valsartan in their binary mixture and in their combined dosage form without prior separation through two manipulation app...
Computational intelligence models to predict porosity of tablets using minimum features.
Drug design, development and therapy
Jan 12, 2017
The effects of different formulations and manufacturing process conditions on the physical properties of a solid dosage form are of importance to the pharmaceutical industry. It is vital to have in-depth understanding of the material properties and g...
Novel Pure Component Contribution Algorithm (PCCA) and UHPLC Methods for Separation and Quantification of Amlodipine, Valsartan, and Hydrochlorothiazide in Ternary Mixture.
Journal of AOAC International
Dec 21, 2016
Two accurate and sensitive methods were developed and validated for the simultaneous determination of amlodipine (AML), valsartan (VAL), and hydrochlorothiazide (HCT) in their ternary mixture. The first method is a novel simple algorithm capable of e...
Analytical Stability-Indicating Methods for Alogliptin in Tablets by LC-CAD and LC-UV.
Journal of AOAC International
Dec 15, 2016
Stability-indicating LC methods using a UV detector and a charged aerosol detector (CAD) simultaneously were validated for the assessment of alogliptin (ALG) in tablets. The analysis was performed on a C8 column (250 × 4.6 mm, 5 μm) at a flow of 0.8 ...
Chromatographic Study of Azintamide in Bulk Powder and in Pharmaceutical Formulation in the Presence of Its Degradation Form.
Journal of AOAC International
Nov 15, 2016
Two specific, sensitive, and precise stability-indicating chromatographic methods were developed, optimized, and validated for the determination of Azintamide (AZ) in the presence of its degradation product. The first method was TLC combined with the...
Artificial Intelligence Tools for Scaling Up of High Shear Wet Granulation Process.
Journal of pharmaceutical sciences
Nov 2, 2016
The results presented in this article demonstrate the potential of artificial intelligence tools for predicting the endpoint of the granulation process in high-speed mixer granulators of different scales from 25L to 600L. The combination of neurofuzz...
A Practical Framework Toward Prediction of Breaking Force and Disintegration of Tablet Formulations Using Machine Learning Tools.
Journal of pharmaceutical sciences
Oct 27, 2016
Enabling the paradigm of quality by design requires the ability to quantitatively correlate material properties and process variables to measureable product performance attributes. Conventional, quality-by-test methods for determining tablet breaking...
First study of the evolution of the SeDeM expert system parameters based on percolation theory: Monitoring of their critical behavior.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Oct 18, 2016
The deep understanding of products and processes has become a requirement for pharmaceutical industries to follow the Quality by Design principles promoted by the regulatory authorities. With this aim, SeDeM expert system was developed as a useful pr...
PLS-LS-SVM based modeling of ATR-IR as a robust method in detection and qualification of alprazolam.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 31, 2016
According to the United States pharmacopeia (USP), Gold standard technique for Alprazolam determination in dosage forms is HPLC, an expensive and time-consuming method that is not easy to approach. In this study chemometrics assisted ATR-IR was intro...
Bioequivalence of fixed-dose combinations of dapagliflozin and metformin with single-component tablets in healthy subjects and the effect of food on bioavailability.
Clinical pharmacology in drug development
Oct 20, 2015
The pharmacokinetics (PK) of dapagliflozin and metformin administered as fixed-dose combination (FDC) tablets (2.5 mg dapagliflozin/850 mg metformin or 5 mg dapagliflozin/1000 mg metformin) or as separate tablets in healthy subjects were evaluated in...
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