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Triglycerides

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-derived postbiotics inhibited digestion of triglycerides, glycerol phospholipids and sterol lipids allosteric regulation of BSSL, PTL and PLA2 to prevent obesity: perspectives on deep learning integrated multi-omics.

Food & function
The anti-obesity potential of probiotics has been widely reported, however their utilization in high-risk patients and potential adverse reactions have led researchers to focus their attention on postbiotics. Herein, pseudo-targeted lipidomics linked...

Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.

Journal of lipid research
Lipolysis is an essential metabolic process that releases unesterified fatty acids from neutral lipid stores to maintain energy homeostasis in living organisms. Adipose triglyceride lipase (ATGL) plays a key role in intracellular lipolysis and can be...

Integrative deep learning framework predicts lipidomics-based investigation of preservatives on meat nutritional biomarkers and metabolic pathways.

Critical reviews in food science and nutrition
Preservatives are added as antimicrobial agents to extend the shelf life of meat. Adding preservatives to meat products can affect their flavor and nutrition. This review clarifies the effects of preservatives on metabolic pathways and network molecu...

Enabling Lipidomic Biomarker Studies for Protected Populations by Combining Noninvasive Fingerprint Sampling with MS Analysis and Machine Learning.

Journal of proteome research
Triacylglycerols and wax esters are two lipid classes that have been linked to diseases, including autism, Alzheimer's disease, dementia, cardiovascular disease, dry eye disease, and diabetes, and thus are molecules worthy of biomarker exploration st...

A comparative evaluation of low-density lipoprotein cholesterol estimation: Machine learning algorithms versus various equations.

Clinica chimica acta; international journal of clinical chemistry
BACKGROUND: Given the critical importance of Low-density lipoprotein cholesterol (LDL-C) levels in determining cardiovascular risk, it is essential to measure LDL-C accurately. Since the Friedewald formula generates incorrect predictions in many circ...

A machine learning analysis of predictors of future hypertension in a young population.

Minerva cardiology and angiology
BACKGROUND: Early diagnosis of hypertension (HT) is crucial for preventing end-organ damage. This study aims to identify the risk factors for future HT in young individuals through the application of machine learning (ML) models.

Comparative Analysis of Chemical Descriptors by Machine Learning Reveals Atomistic Insights into Solute-Lipid Interactions.

Molecular pharmaceutics
This study explores the research area of drug solubility in lipid excipients, an area persistently complex despite recent advancements in understanding and predicting solubility based on molecular structure. To this end, this research investigated no...

Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort.

Age and ageing
BACKGROUND: A number of biomarkers denoting various pathophysiological pathways have been implicated in the aetiology and risk of age-related diseases. Hence, the combined impact of multiple biomarkers in relation to ageing free of major chronic dise...

Predicting stroke severity of patients using interpretable machine learning algorithms.

European journal of medical research
BACKGROUND: Stroke is a significant global health concern, ranking as the second leading cause of death and placing a substantial financial burden on healthcare systems, particularly in low- and middle-income countries. Timely evaluation of stroke se...

Machine Learning Reveals the Contribution of Lipoproteins to Liver Triglyceride Content and Inflammation.

The Journal of clinical endocrinology and metabolism
CONTEXT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide and is strongly associated with metabolic comorbidities, including dyslipidemia.