International journal of molecular sciences
Oct 30, 2024
Drug substances in water bodies and groundwater have become a significant threat to the surrounding environment. This study focuses on the ability of the nanoporous carbon materials to remove ciprofloxacin from aqueous solutions under specific experi...
International journal of molecular sciences
Oct 30, 2024
Understanding the effect of single-missense mutations on protein stability is crucial for clinical decision-making and therapeutic development. The impact of these mutations on protein stability and 3D structure remains underexplored. Here, we develo...
International journal of molecular sciences
Oct 30, 2024
Reliable predictors of long-term all-cause mortality are needed for middle-aged and older populations. Previous metabolomics mortality studies have limitations: a low number of participants and metabolites measured, measurements mainly using nuclear ...
International journal of molecular sciences
Oct 29, 2024
To date, the public health system has been impacted by the increasing costs of many diagnostic and therapeutic pathways due to limited resources. At the same time, we are constantly seeking to improve these paths through approaches aimed at personali...
International journal of molecular sciences
Oct 22, 2024
Prostate cancer (PCa) poses a significant global health challenge, particularly due to its progression into aggressive forms like neuroendocrine prostate cancer (NEPC). This study developed and validated a stemness-associated gene signature using adv...
International journal of molecular sciences
Sep 26, 2024
The pathogenesis of cancer is complex, involving abnormalities in some genes in organisms. Accurately identifying cancer genes is crucial for the early detection of cancer and personalized treatment, among other applications. Recent studies have used...
International journal of molecular sciences
Sep 25, 2024
Fabry disease (FD) is an X-linked lysosomal disease whose ultimate consequences are the accumulation of sphingolipids and subsequent inflammatory events, mainly at the endothelial level. The outcomes include different nervous system manifestations as...
International journal of molecular sciences
Sep 25, 2024
Intraventricular hemorrhage (IVH) in preterm neonates presents a high risk for developing posthemorrhagic ventricular dilatation (PHVD), a severe complication that can impact survival and long-term outcomes. Early detection of PHVD before clinical on...
International journal of molecular sciences
Sep 24, 2024
Protamines play a critical role in DNA compaction and stabilization in sperm cells, significantly influencing male fertility and various biotechnological applications. Traditionally, identifying these proteins is a challenging and time-consuming proc...
International journal of molecular sciences
Sep 23, 2024
Repurposing utilizes existing drugs with known safety profiles and discovers new uses by combining experimental and computational approaches. The integration of computational methods has greatly advanced drug repurposing, offering a rational approach...