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Age Factors

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Prediction of cognitive impairment via deep learning trained with multi-center neuropsychological test data.

BMC medical informatics and decision making
BACKGROUND: Neuropsychological tests (NPTs) are important tools for informing diagnoses of cognitive impairment (CI). However, interpreting NPTs requires specialists and is thus time-consuming. To streamline the application of NPTs in clinical settin...

Predicting atrial fibrillation in primary care using machine learning.

PloS one
BACKGROUND: Atrial fibrillation (AF) is the most common sustained heart arrhythmia. However, as many cases are asymptomatic, a large proportion of patients remain undiagnosed until serious complications arise. Efficient, cost-effective detection of t...

Deep neural networks and kernel regression achieve comparable accuracies for functional connectivity prediction of behavior and demographics.

NeuroImage
There is significant interest in the development and application of deep neural networks (DNNs) to neuroimaging data. A growing literature suggests that DNNs outperform their classical counterparts in a variety of neuroimaging applications, yet there...

Multimodal fusion of structural and functional brain imaging in depression using linked independent component analysis.

Human brain mapping
Previous structural and functional neuroimaging studies have implicated distributed brain regions and networks in depression. However, there are no robust imaging biomarkers that are specific to depression, which may be due to clinical heterogeneity ...

A deep learning model for pediatric patient risk stratification.

The American journal of managed care
OBJECTIVES: Current models for patient risk prediction rely on practitioner expertise and domain knowledge. This study presents a deep learning model-a type of machine learning that does not require human inputs-to analyze complex clinical and financ...

A comprehensive knowledge base of synaptic electrophysiology in the rodent hippocampal formation.

Hippocampus
The cellular and synaptic architecture of the rodent hippocampus has been described in thousands of peer-reviewed publications. However, no human- or machine-readable public catalog of synaptic electrophysiology data exists for this or any other neur...

Investigation of bias in an epilepsy machine learning algorithm trained on physician notes.

Epilepsia
Racial disparities in the utilization of epilepsy surgery are well documented, but it is unknown whether a natural language processing (NLP) algorithm trained on physician notes would produce biased recommendations for epilepsy presurgical evaluation...

Automated lesion segmentation with BIANCA: Impact of population-level features, classification algorithm and locally adaptive thresholding.

NeuroImage
White matter hyperintensities (WMH) or white matter lesions exhibit high variability in their characteristics both at population- and subject-level, making their detection a challenging task. Population-level factors such as age, vascular risk factor...