AIMC Topic: Aged, 80 and over

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Analysis of TEM micrographs with deep learning reveals APOE genotype-specific associations between HDL particle diameter and Alzheimer's dementia.

Cell reports methods
High-density lipoprotein (HDL) particle diameter distribution is informative in the diagnosis of many conditions, including Alzheimer's disease (AD). However, obtaining an accurate HDL size measurement is challenging. We demonstrated the utility of m...

Potential Impact of an Artificial Intelligence-based Mammography Triage Algorithm on Performance and Workload in a Population-based Screening Sample.

Journal of breast imaging
OBJECTIVE: To evaluate potential screening mammography performance and workload impact using a commercial artificial intelligence (AI)-based triage device in a population-based screening sample.

Artificial Intelligence in Predicting Ocular Hypertension After Descemet Membrane Endothelial Keratoplasty.

Investigative ophthalmology & visual science
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) has emerged as a novel approach in corneal transplantation over the past two decades. This study aims to identify predisposing risk factors for post-DMEK ocular hypertension (OHT) and develop...

Sarcopenia prediction model based on machine learning and SHAP values for community-based older adults with cardiovascular disease in China.

Frontiers in public health
BACKGROUND: Sarcopenia (SP), is recognized as a complication of cardiovascular disease (CVD), but few relevant diagnostic models have been developed. This study aims to establish an interpretable diagnostic model for the occurrence of SP in older adu...

Deep learning reconstruction of free-breathing, diffusion-weighted imaging of the liver: A comparison with conventional free-breathing acquisition.

PloS one
This study aimed to compare image quality and solid focal liver lesion (FLL) assessments between free-breathing, diffusion-weighted imaging using deep learning reconstruction (FB-DL-DWI) and conventional DWI (FB-C-DWI) in patients undergoing clinical...

Urban-rural disparities in fall risk among older Chinese adults: insights from machine learning-based predictive models.

Frontiers in public health
BACKGROUND: Falls among older adults are a significant challenge to global healthy aging. Identifying key factors and differences in fall risks, along with developing predictive models, is essential for differentiated and precise interventions in Chi...

Artificial intelligence and omics-based autoantibody profiling in dementia.

Frontiers in immunology
INTRODUCTION: Dementia is a neurodegenerative syndrome marked by the accumulation of disease-specific proteins and immune dysregulation, including autoimmune mechanisms involving autoantibodies. Current diagnostic methods are often invasive, time-con...

A Real-Time Plasma Concentration Prediction Model for Voriconazole in Elderly Patients via Machine Learning Combined with Population Pharmacokinetics.

Drug design, development and therapy
PURPOSE: Voriconazole (VCZ) is a first-line treatment for invasive fungal disease, characterized by a narrow therapeutic window and significant inter-individual variability. It is primarily metabolized by the liver, the function of which declines wit...

Comprehensive Machine Learning-Based Prediction Model for Delirium Risk in Older Patients with Dementia: Risk Factors Identification.

Clinical interventions in aging
BACKGROUND: Delirium superimposed on dementia (DSD) is a severe complication in older adults with dementia, marked by fluctuating cognition, inattention, and altered consciousness. Detection is challenging due to symptom overlap, yet it contributes t...

All-Cause Mortality Risk in Elderly Patients with Femoral Neck and Intertrochanteric Fractures: A Predictive Model Based on Machine Learning.

Clinical interventions in aging
INTRODUCTION: The aim of this study was to identify the influencing factors for all-cause mortality in elderly patients with intertrochanteric and femoral neck fractures and to construct predictive models.