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Identifying key physiological and clinical factors for traumatic brain injury patient management using network analysis and machine learning.
PloS one
Jul 28, 2025
In the intensive care unit (ICU), managing traumatic brain injury (TBI) patients presents significant challenges due to the dynamic interaction between physiological and clinical markers. This study aims to uncover these subtle interconnections and i...
Disease activity and treatment response in early rheumatoid arthritis: an exploratory metabolomic profiling in the NORD-STAR cohort.
Arthritis research & therapy
Jul 26, 2025
BACKGROUND: The variability in treatment response in people with rheumatoid arthritis (RA) warrants the prediction of patients at high risk of treatment failure. Identification of biomarkers linked to clinical remission in RA is currently a challenge...
Machine learning-based dynamic CEA trajectory and prognosis in gastric cancer.
BMC cancer
Jul 26, 2025
BACKGROUND: Static carcinoembryonic antigen (CEA) levels are well‑established prognostic markers in patients with gastric cancer, but the significance of their dynamic trajectories over time has rarely been reported.
Identifying patterns of high intraoperative blood pressure variability in noncardiac surgery using explainable machine learning: a retrospective cohort study.
Annals of medicine
Jul 24, 2025
BACKGROUND: High intraoperative blood pressure variability (HIBPV) is significantly associated with postoperative adverse complications. However, practical tools to characterize perioperative factors associated with HIBPV remain limited. This study a...
Comparative analysis of the tumor microenvironment in primary CNS and testicular large B-cell lymphomas using digital image analysis and its implications for immunotherapy.
Human pathology
Jul 24, 2025
Primary large B-cell lymphomas of immune-privileged sites, including primary central nervous system lymphoma (PCNSL) and primary testicular lymphoma (PTL), exhibit distinct clinicopathologic features contributing to aggressive behavior and immune eva...
Familial Differences in Personal PM Exposure within a Rural African Community Explained with Spatiotemporal Exposure Apportionment.
Environmental science & technology
Jul 24, 2025
Exposure to fine particulate matter (PM) from solid-fuel combustion is a major determinant of global morbidity and mortality. However, variations in exposure remain uncertain across many high-risk populations. This work describes personal PM exposure...
Development and validation of machine learning-based risk prediction models for ICU-acquired weakness: a prospective cohort study.
European journal of medical research
Jul 24, 2025
BACKGROUND: Intensive care unit (ICU)-acquired weakness (ICUAW) is a prevalent complication in critically ill patients, marked by symmetrical respiratory and limb muscle weakness, which adversely affects long-term outcomes. Early identification of hi...
Effects and neural mechanisms of a brain-computer interface-controlled soft robotic glove on upper limb function in patients with subacute stroke: a randomized controlled fNIRS study.
Journal of neuroengineering and rehabilitation
Jul 24, 2025
BACKGROUND AND PURPOSE: The brain-computer interface-based soft robotic glove (BCI-SRG) holds promise for upper limb rehabilitation in subacute stroke patients, yet its efficacy and neural mechanisms are unclear. This study aimed to investigate the t...
Optimized feature selection and advanced machine learning for stroke risk prediction in revascularized coronary artery disease patients.
BMC medical informatics and decision making
Jul 24, 2025
BACKGROUND: Coronary artery disease (CAD) remains a leading cause of global mortality, with stroke constituting a significant complication among patients undergoing coronary revascularization procedures, such as percutaneous coronary intervention (PC...
Beyond labels: determining the true type of blood gas samples in ICU patients through supervised machine learning.
BMC medical informatics and decision making
Jul 24, 2025
BACKGROUND: In the Intensive Care Unit (ICU), data stored in patient data management systems (PDMS) is commonly used in clinical practice and research. Parameters from point-of-care arterial blood gas (BG) analysis are used in the diagnosis and defin...
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