AIMC Topic: Alzheimer Disease
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Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state.
Science advances
Jun 11, 2025
Amyloid aggregates are pathological hallmarks of many human diseases, but how soluble proteins nucleate to form amyloids is poorly understood. Here, we use combinatorial mutagenesis, a kinetic selection assay, and machine learning to massively pertur...
An ensemble-based 3D residual network for the classification of Alzheimer's disease.
PloS one
Jun 11, 2025
Alzheimer's disease (AD) is a common type of dementia, with mild cognitive impairment (MCI) being a key precursor. Early MCI diagnosis is crucial for slowing AD progression, but distinguishing MCI from normal controls (NC) is challenging due to subtl...
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Nature communications
Jun 4, 2025
Mitophagy, the selective autophagic elimination of mitochondria, is essential for maintaining mitochondrial quality and cell homeostasis. Impairment of mitophagy flux, a process involving multiple sequential intermediates, is implicated in the onset ...
Dynamically weighted graph neural network for detection of early mild cognitive impairment.
PloS one
Jun 4, 2025
Alzheimer's disease (AD) is a prevalent neurodegenerative disease that primarily affects the elderly population. The early detection of mild cognitive impairment (MCI) holds significant clinical importance for prompt intervention and treatment of AD....
Role of astroglia and microglia in Alzheimer's disease and multiple therapeutic interventions.
Journal of Alzheimer's disease : JAD
Jun 2, 2025
Alzheimer's disease (AD) is characterized by deposition of amyloid-β (Aβ) and neurofibrillary tangles (NFTs) formed by aggregates of hyperphosphorylated tau proteins. It presents a formidable global health challenge, prompting the exploration of inno...
Operationalizing postmortem pathology-MRI association studies in Alzheimer's disease and related disorders with MRI-guided histology sampling.
Acta neuropathologica communications
May 28, 2025
Postmortem neuropathological examination, while the gold standard for diagnosing neurodegenerative diseases, often relies on limited regional sampling that may miss critical areas affected by Alzheimer's disease and related disorders. Ultra-high reso...
Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy.
EBioMedicine
May 27, 2025
BACKGROUND: The impact of high body mass index (BMI) states and associated proteomic factors on brain ageing and Alzheimer's disease (AD) remains unclear.
Identification of shared mechanisms between Alzheimer's disease and atherosclerosis by integrated bioinformatics analysis.
European journal of medical research
May 22, 2025
Alzheimer's disease (AD) and atherosclerosis (AS) are two interacting diseases mostly affecting aged adults. AD is characterized by the deposition of neuritic plaques mainly consisting of Aβ, and AS is defined by the formation of atheromatous plaque ...
Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer's disease.
Scientific reports
May 17, 2025
The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accurately identify optimal candidates for anti-amyloid therapy, specifically those with evidence for inc...
Early detection of Alzheimer's disease progression stages using hybrid of CNN and transformer encoder models.
Scientific reports
May 14, 2025
Alzheimer's disease (AD) is a neurodegenerative disorder that affects memory and cognitive functions. Manual diagnosis is prone to human error, often leading to misdiagnosis or delayed detection. MRI techniques help visualize the fine tissues of the ...
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