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Alzheimer Disease

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Artificial Intelligence Based Hierarchical Classification of Frontotemporal Dementia.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Frontotemporal dementia (FTD) is a typical kind of presenile dementia with three main subtypes: behavioral-variant FTD (bvFTD), non-fluent variant primary progressive aphasia (nfvPPA), and semantic variant primary progressive aphasia (svPPA). Our aim...

3D Multi-feature fusion convolutional network for Alzheimer's disease diagnosis.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
The cognitive decline caused by Alzheimer's disease (AD) is closely related to the structural changes in the hippocampus captured by structural magnetic resonance imaging (sMRI). However, current deep model research on the morphological analysis of h...

Novel Alzheimer's Disease Stating Based on Comorbidities-Informed Graph Neural Networks.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Alzheimer's Disease (AD), the most prevalent form of dementia, requires early prediction for timely intervention. Leveraging data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), our study employs Graph Neural Networks (GNNs) for multi-cl...

Dual Attention Graph Convolutional Network Fusing Imaging and Genetic Data for Early Alzheimer's Disease Diagnosis.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Alzheimer's Disease (AD) poses a significant global neurodegenerative challenge, underscoring the urgency of early clinical intervention. Our paper presents a novel approach for early AD diagnosis, focusing on a dual attention graph convolutional net...

Brain Age Analysis and Dementia Classification using Convolutional Neural Networks trained on Diffusion MRI: Tests in Indian and North American Cohorts.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Deep learning models based on convolutional neural networks (CNNs) have been used to classify Alzheimer's disease or infer dementia severity from T1-weighted brain MRI scans. Here, we examine the value of adding diffusion-weighted MRI (dMRI) as an in...

Graph-based deep learning models in the prediction of early-stage Alzheimers.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Alzheimer's disease is the most common age-related problem and progresses in different stages, from cognitively normal to early mild cognitive impairment, and severe dementia. This study investigates the predictive potential of resting-state function...

The More, the Better? Evaluating the Role of EEG Preprocessing for Deep Learning Applications.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
The last decade has witnessed a notable surge in deep learning applications for electroencephalography (EEG) data analysis, showing promising improvements over conventional statistical techniques. However, deep learning models can underperform if tra...

Deep learning-based cell-specific gene regulatory networks inferred from single-cell multiome data.

Nucleic acids research
Gene regulatory networks (GRNs) provide a global representation of how genetic/genomic information is transferred in living systems and are a key component in understanding genome regulation. Single-cell multiome data provide unprecedented opportunit...

Hyperfusion: A hypernetwork approach to multimodal integration of tabular and medical imaging data for predictive modeling.

Medical image analysis
The integration of diverse clinical modalities such as medical imaging and the tabular data extracted from patients' Electronic Health Records (EHRs) is a crucial aspect of modern healthcare. Integrative analysis of multiple sources can provide a com...

Applying machine learning to high-dimensional proteomics datasets for the identification of Alzheimer's disease biomarkers.

Fluids and barriers of the CNS
PURPOSE: This study explores the application of machine learning to high-dimensional proteomics datasets for identifying Alzheimer's disease (AD) biomarkers. AD, a neurodegenerative disorder affecting millions worldwide, necessitates early and accura...