AIMC Topic: Animals
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Unique bioaccumulation and biosynthesis of arsenobetaine in marine fish.
Aquatic toxicology (Amsterdam, Netherlands)
May 24, 2025
Arsenic (As) contamination represents a significant global concern, particularly prevalent in regions such as China, South Asia, and Southeast Asia. Arsenic permeates the food chain, posing potential hazards to ecosystems and human health. Studies ha...
Novel Computational Approaches in the Discovery and Identification of Bioactive Peptides: A Bioinformatics Perspective.
Journal of agricultural and food chemistry
May 24, 2025
Bioactive peptides are protein molecules known for their specific biological functions, offering promising applications across various fields including medicine, food, and cosmetics. Traditional approaches to the investigation of bioactive peptides t...
The Role of Hydrogen Sulfide in the Localization and Structural-Functional Organization of p53 Following Traumatic Brain Injury: Development of a YOLO Model for Detection and Quantification of Apoptotic Nuclei.
International journal of molecular sciences
May 24, 2025
Traumatic brain injury (TBI) triggers a cascade of molecular and cellular disturbances, including apoptosis, inflammation, and destabilization of neuronal connections. The transcription factor p53 plays a pivotal role in regulating cell fate followin...
Continuous automated analysis of facial dynamics of brachycephalic and normocephalic dogs in different contexts.
BMC veterinary research
May 24, 2025
This study develops a novel automated method for measuring continuous dynamics of dog facial behavior based on video-based tracking of 46 facial landmarks grounded in the Dog Facial Action Coding System. This method is applied for comparing the facia...
Image guided construction of a common coordinate framework for spatial transcriptome data.
Scientific reports
May 24, 2025
Spatial transcriptomics is a powerful technology for high-resolution mapping of gene expression in tissue samples, enabling a molecular level understanding of tissue architecture. The acquisition entails dissecting and profiling micron-thick tissue s...
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.
Free radical biology & medicine
May 23, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Disease Models, Animal
Hep G2 Cells
Phenylenediamines
Humans
Cyclin-Dependent Kinase Inhibitor p21
Early Growth Response Protein 1
Ferroptosis
Animals
Mice, Inbred C57BL
Male
Non-alcoholic Fatty Liver Disease
Gene Expression Regulation
Liver
Mice
Endoplasmic Reticulum Stress
Diet, High-Fat
Fatty Liver
Machine learning Reveals ATM and CNOT6L as critical factors in Cataract pathogenesis.
Experimental eye research
May 23, 2025
OBJECTIVE: Cataract, a common age-related blinding eye disease, has a complex pathogenesis. This study aims to identify key genes and potential mechanisms associated with cataracts, offering new targets and insights for its prevention and treatment.
Neuron-astrocyte associative memory.
Proceedings of the National Academy of Sciences of the United States of America
May 23, 2025
Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, there are no current theories that explain how neurons, synapses, and astrocytes might collectivel...
Machine Learning-Based Analysis of Differentially Expressed Genes in the Muscle Transcriptome Between Beef Cattle and Dairy Cattle.
International journal of molecular sciences
May 23, 2025
Muscle is a crucial component of cattle, playing a vital role in determining the final quality of beef. This study aimed to identify candidate genes associated with muscle growth and lipid metabolism in beef and dairy cattle by utilizing the public d...
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.
Nature communications
May 23, 2025
Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based mult...
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