Pine wood nematode disease (PWD) is one of the most devastating forest diseases worldwide, often described as the "cancer" of pine trees due to its rapid and large-scale lethality. Early and accurate detection of infected trees is essential for inter...
BACKGROUND: Automated behavior monitoring is increasingly important in precision dairy farming, supporting early disease detection, welfare assessment, and productivity optimization. Although accelerometers effectively detect postural changes, they h...
Signature-based protein detection coupled with machine learning algorithms has revolutionized traditional sensing methods, providing rapid, inexpensive, and selectivity-driven detection without the use of specialized equipment. This strategy leverage...
The lack of safe, durable therapeutics that act against both biological aging and Alzheimer's disease is an unmet clinical need. To bridge this gap, we devised an artificial intelligence (AI)-enabled approach that pairs rapid compound triage with mec...
This study develops a discrete-time predator-prey model for guava pest management using the piecewise constant argument (PCA) scheme. The model incorporates logistic prey growth, neem-induced mortality, and predator crowding. Analytical and numerical...
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most prevalent genetic kidney disorder. Animal preclinical studies are one of the main tools to study this disease, often through either 2D histology imaging for high-resolution analysis or ...
Predicting protein‒protein interactions (PPIs) plays a crucial role in understanding biological processes. Although biological experimental methods can identify PPIs, they are costly, time-consuming, labor-intensive, and often lack stability. In cont...
BACKGROUND: Single-cell RNA sequencing (scRNA-seq) provides extensive opportunities to explore cellular heterogeneity but is often limited by substantial technical noise and variability. The prevalence of zero counts, arising from both biological var...
Phosphodiesterase 4 (PDE4) has been validated as a promising therapeutic target for idiopathic pulmonary fibrosis (IPF), a devastating interstitial lung disease lacking really effective therapeutic drugs, particularly exacerbated in the post-COVID-19...
Proceedings of the National Academy of Sciences of the United States of America
Nov 18, 2025
The architectures of biological neural networks result from developmental processes shaped by genetically encoded rules, biophysical constraints, stochasticity, and learning. Understanding these processes is crucial for comprehending neural circuits'...
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