The spatial organization of cells plays a pivotal role in shaping tissue functions and phenotypes in various biological systems and diseased microenvironments. However, the topological principles governing interactions among cell types within spatial...
Many genome-wide studies capture isolated moments in cell differentiation or organismal development. Conversely, longitudinal studies provide a more direct way to study these kinetic processes. Here, we present an approach for modeling gene-expressio...
High-throughput screening of deep eutectic solvents (DESs) was performed using artificial intelligence/quantum mechanical models. Ni-amorphous metal-organic frameworks (aMOFs) was synthesized through amine-DES aqueous solution. The target-specific DE...
Journal of controlled release : official journal of the Controlled Release Society
Aug 18, 2025
Nano-sized drug delivery systems have emerged as a more effective, versatile means for improving cancer treatment. However, the complexity of drug delivery to cancer involves intricate interactions between physiological and physicochemical processes ...
Proceedings of the National Academy of Sciences of the United States of America
Aug 18, 2025
Fish population biomass fluctuates through time in ways that may be either gradual or abrupt. While abrupt shifts in fish population productivity have been shown to be common, they are rarely integrated into stock assessment or fishery management, in...
Rheumatoid arthritis (RA) is a systemic autoimmune disease shaped by complex interactions between genetics and environmental factors, among which gut microbiota has emerged as a critical modulator. Recent advances have implicated gut microbiota dysbi...
International journal of pharmaceutics
Aug 16, 2025
This study aimed to explore the potential of a Machine learning (ML)-integrated Quality by design (QbD) process to formulate resveratrol (RES)-loaded polymeric nanoparticles (RES-PNPs) for potential use in transdermal drug delivery. The RES-PNPs were...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 15, 2025
Vascular aging-related remodeling is a common pathological basis for many chronic diseases, so early detection of physical arterial aging is important for their prevention and control. Existing staining methods can only analyze a limited number of ti...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 15, 2025
Diabetic encephalopathy is a progressive complication of type 2 diabetes, yet its region-specific biochemical changes remain unclear. In this study, we applied Fourier Transform Infrared Microspectroscopy (FTIRM) to assess metabolic alterations in th...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 14, 2025
Hyperspectral imaging, as an emerging medical imaging technology, offers significant potential in biomedical research due to its ability in capturing rich spectral information. An enhanced bi-branch network integrating graph convolutional network (GC...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.