AIMC Topic: Animals

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4-Hydroxyboesenbergin B of Alpinia japonica protected gastrointestinal tract by inhibiting vancomycin-resistant enterococcus and balancing intestinal microbiota.

Journal of ethnopharmacology Apr 1, 2025
ETHNOPHARMACOLOGICAL RELEVANCE: Alpinia japonica, a traditional herb utilized in Miao medicine in southwestern China, has been employed to alleviate symptoms such as stomachache, diarrhea, and abdominal pain, some of these symptoms may be associated ...
Mice Male Gastrointestinal Microbiome Biofilms Gastrointestinal Tract Anti-Bacterial Agents Microbial Sensitivity Tests Vancomycin-Resistant Enterococci Animals Alpinia
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Advances in AAV capsid engineering: Integrating rational design, directed evolution and machine learning.

Molecular therapy : the journal of the American Society of Gene Therapy Apr 1, 2025
Adeno-associated virus (AAV) has emerged as a highly promising vector for human gene therapy due to its favorable safety profile, versatility, and ability to transduce a wide range of tissues. However, natural AAV serotypes have shortcomings, includi...
Genetic Therapy Directed Molecular Evolution Genetic Vectors Transduction, Genetic Capsid Proteins Capsid Humans Machine Learning Genetic Engineering Animals Dependovirus
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Enhancing cell instance segmentation in scanning electron microscopy images via a deep contour closing operator.

Computers in biology and medicine Apr 1, 2025
Accurately segmenting and individualizing cells in scanning electron microscopy (SEM) images is a highly promising technique for elucidating tissue architecture in oncology. While current artificial intelligence (AI)-based methods are effective, erro...
Image Processing, Computer-Assisted Mice Microscopy, Electron, Scanning Animals Deep Learning Humans Neural Networks, Computer
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Enhancing synchrotron radiation micro-CT images using deep learning: an application of Noise2Inverse on bone imaging.

Journal of synchrotron radiation Apr 1, 2025
In bone-imaging research, in situ synchrotron radiation micro-computed tomography (SRµCT) mechanical tests are used to investigate the mechanical properties of bone in relation to its microstructure. Low-dose computed tomography (CT) is used to prese...
Radiation Dosage Animals Bone and Bones Deep Learning X-Ray Microtomography Synchrotrons Image Processing, Computer-Assisted
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Interpreting regulatory mechanisms of Hippo signaling through a deep learning sequence model.

Cell genomics Apr 1, 2025
Signaling pathway components are well studied, but how they mediate cell-type-specific transcription responses is an unresolved problem. Using the Hippo pathway in mouse trophoblast stem cells as a model, we show that the DNA binding of signaling eff...
Hippo Signaling Pathway YAP-Signaling Proteins TEA Domain Transcription Factors Mice Trophoblasts Signal Transduction Enhancer Elements, Genetic Transcription Factors Muscle Proteins Protein Serine-Threonine Kinases Molecular Dynamics Simulation Adaptor Proteins, Signal Transducing Phosphoproteins DNA-Binding Proteins Animals Deep Learning Protein Binding
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A robust and omnidirectional-sensitive electronic antenna for tactile-induced perception.

Nature communications Apr 1, 2025
Skin-like planar tactile sensors have achieved adaptive gripping, in-hand manipulation, and human-machine interaction but remain limited in tasks requiring active environmental interaction and robustness against large mechanical perturbations. Inspir...
Robotics Electronics Insecta Humans Algorithms Animals Touch Touch Perception
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Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research.

Biotechnology advances Apr 1, 2025
Human settlements on the Moon, crewed missions to Mars and space tourism will become a reality in the next few decades. Human presence in space, especially for extended periods of time, will therefore steeply increase. However, despite more than 60 y...
Biological Science Disciplines Animal Testing Alternatives Space Flight Humans Animals
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A machine learning computational approach for the mathematical anthrax disease system in animals.

PloS one Apr 1, 2025
OBJECTIVES: The current research investigations present the numerical solutions of the anthrax disease system in animals by designing a machine learning stochastic procedure. The mathematical anthrax disease system in animals is classified into susce...
Animals Bayes Theorem Stochastic Processes Machine Learning Algorithms Bacillus anthracis Anthrax
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Explainable classification of goat vocalizations using convolutional neural networks.

PloS one Apr 1, 2025
Efficient precision livestock farming relies on having timely access to data and information that accurately describes both the animals and their surrounding environment. This paper advances classification of goat vocalizations leveraging a publicly ...
Acoustics Vocalization, Animal Machine Learning Animals Goats Neural Networks, Computer
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Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii.

Journal of applied toxicology : JAT Mar 31, 2025
Serendipity Berry Sweet Protein (sweelin) is a novel hyper-sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI-CPD) to improve the stability and sensory profile of the protein found in serendipity berry ...
Female Animals Fruit No-Observed-Adverse-Effect Level Mutagenicity Tests Male Rats Rats, Sprague-Dawley
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