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Anti-Bacterial Agents

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Fusaroxazin, a novel cytotoxic and antimicrobial xanthone derivative from .

Natural product research
Oxazines and their derivatives are an uncommon natural heterocyclic compounds, which contain oxygen and nitrogen atoms and possess various bioactivities. A novel 1,4-oxazine-xanthone derivative, fusarioxazin () and three known sterols () were separat...

Temporal variation and sharing of antibiotic resistance genes between water and wild fish gut in a peri-urban river.

Journal of environmental sciences (China)
Antibiotic resistance genes (ARGs) as emergence contaminations have spread widely in the water environment. Wild fish may be recipients and communicators of ARGs in the water environment, however, the distribution and transmission of ARGs in the wild...

Deep Learning Analysis of Vibrational Spectra of Bacterial Lysate for Rapid Antimicrobial Susceptibility Testing.

ACS nano
Rapid antimicrobial susceptibility testing (AST) is an integral tool to mitigate the unnecessary use of powerful and broad-spectrum antibiotics that leads to the proliferation of multi-drug-resistant bacteria. Using a sensor platform composed of surf...

Weissella cibaria EIR/P2-derived exopolysaccharide: A novel alternative to conventional biomaterials targeting periodontal regeneration.

International journal of biological macromolecules
Healing and regeneration of periodontium are considered as a complex physiological process. Therefore, treatments need to be addressed with highly effective components modulating the multiple pathways. In this study, exopolysaccharide (EPS) produced ...

Predicting antimicrobial resistance using conserved genes.

PLoS computational biology
A growing number of studies are using machine learning models to accurately predict antimicrobial resistance (AMR) phenotypes from bacterial sequence data. Although these studies are showing promise, the models are typically trained using features de...

A Study of the Chemistries, Growth Mechanisms, and Antibacterial Properties of Cerium- and Yttrium-Containing Nanoparticles.

ACS biomaterials science & engineering
Under the current climate, physicians prescribe antibiotics for treating bacterial infections, and such a limitation to a single class of drugs is disadvantageous since antibiotic-resistant bacteria have adapted to withstanding their stresses. Antibi...

PeptiDesCalculator: Software for computation of peptide descriptors. Definition, implementation and case studies for 9 bioactivity endpoints.

Proteins
We present a novel Java-based program denominated PeptiDesCalculator for computing peptide descriptors. These descriptors include: redefinitions of known protein parameters to suite the peptide domain, generalization schemes for the global descriptio...

Understanding and predicting ciprofloxacin minimum inhibitory concentration in Escherichia coli with machine learning.

Scientific reports
It is important that antibiotics prescriptions are based on antimicrobial susceptibility data to ensure effective treatment outcomes. The increasing availability of next-generation sequencing, bacterial whole genome sequencing (WGS) can facilitate a ...

Improved Antibiotic Detection in Raw Milk Using Machine Learning Tools over the Absorption Spectra of a Problem-Specific Nanobiosensor.

Sensors (Basel, Switzerland)
In this article we present the development of a biosensor system that integrates nanotechnology, optomechanics and a spectral detection algorithm for sensitive quantification of antibiotic residues in raw milk of cow. Firstly, nanobiosensors were des...

Application of artificial neural networks to prediction of new substances with antimicrobial activity against Escherichia coli.

Journal of applied microbiology
AIMS: This article presents models of artificial neural networks (ANN) employed to predict the biological activity of chemical compounds based of their structure. Regression and classification models were designed to determine antimicrobial propertie...